Molecular basis of protein-ligand interactions.

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The long-term objective of this research program is to understand the molecular mechanisms and functional consequences of proteins-ligand interactions. We are especially interested in proteins that interact with metal ions and/or other proteins because there are still important gaps in our understanding of how proteins recognize these ligands. Viral proteins are especially well suited for these studies because a single protein frequently harbors many different enzymatic activities and can therefore interact with various ligands. In the current research program, we are focusing on the NS5A protein from the Hepatitis C virus (HCV). We believe that understanding the functions of NS5A could lead to an improved knowledge of HCV infection and viral propagation.