Molecular mechanism of RNA modification

RNA修饰的分子机制

• 批准号: 341996-2009
• 负责人: Kothe, Ute
• 金额: $ 2.19万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=527554
• 关键词: Molecular; mechanism; RNA; modification

In each living cell, large and complex machines called ribosomes synthesize all proteins. These protein factories consist themselves of two different biomolecules, namely proteins and RNAs. RNAs are nucleic acids resembling DNA, the genetic material. However in contrast to DNA, RNA can not only store information, but it has also functional roles within the cell similar to proteins. Thus, RNA is the third major biomolecule acting in our cells. The importance of RNA in carrying out crucial biochemical actions has been recognized by several recent Nobel prizes.

在每个活细胞中，被称为核糖体的大型复杂机器合成所有蛋白质。这些蛋白质工厂本身由两个不同的生物分子组成，即蛋白质和RNA。RNA是类似于遗传物质DNA的核酸。然而，与DNA不同的是，RNA不仅可以存储信息，而且在细胞内也具有类似于蛋白质的功能。因此，RNA是作用于我们细胞的第三大生物分子。最近的几个诺贝尔奖已经承认了RNA在执行关键的生化行动中的重要性。