Nanomechanical gas chromatography for metabolite detection and breath analysis

用于代谢物检测和呼吸分析的纳米机械气相色谱

• 批准号: 356093-2013
• 负责人: Hiebert, Wayne
• 金额: $ 1.53万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528029
• 关键词: Nanomechanical; gas; chromatography; metabolite; detection

Nanosensors continue to attract intense research attention for physical, chemical, and biological analysis due to intriguing properties like exceptional sensitivity and the promise of portability. Nanomechanical systems are one example: their surprising capability to weigh individual molecules has established their immense sensing potential. Gas chromatography is a very powerful analytical technique where broader portable adoption will benefit a wide swath of applications ranging from environmental monitoring to disease diagnosis. The main objective of this program is to incorporate nanomechanical sensing into gas chromatography to provide enhanced functionality. The ultimate goal is robust detection and identification of gas molecules by inexpensive portable platforms. Building on our past strengths, three interrelated objectives will focus our efforts in working towards these goals. 1) The sensitivity of nanomechanical systems will be pushed towards an ultimate limit. 2) A novel gas microchannel system will be developed and exploited to best take advantage of this sensitivity. 3) The analytical power of nanomechanical sensors will be broadened by studying deployments which provide additional information (such as arrays of different sensor coatings). These efforts will be carried out as the nanomechanical sensors are compared to regular sensors during gas chromatography of real compounds such as disease biomarkers. The platform created in this program will have immediate impacts in the fields of nanophotonics, nanomechanics, gas chromatography, and analytical sensing. The anticipated significance includes elucidation of the rapidly growing combined fields of photonics and nanomechanics, the development of a new gas chromatography technique, better limits of detection with improved gas molecule recognition, new methods for biomarker profiling, and ubiquitous accessible chemical analysis. Undergraduate and graduate students will be trained to a high level in a unique multi-disciplinary environment of nanofabrication, photonics, nanomechanics, chromatography, and metabolomics expertise and analytical and optoelectronic instrumentation.

纳米传感器继续引起人们对物理，化学和生物学分析的强烈研究，这是由于具有特殊敏感性和便携性的希望而引起的。 纳米力学系统是一个例子：称重单个分子的惊人能力已经确定了它们的巨大感测潜力。 气相色谱法是一种非常强大的分析技术，在该技术中，更广泛的便携式采用率将使从环境监测到疾病诊断等广泛应用。 该程序的主要目的是将纳米力学传感纳入气相色谱法以提供增强的功能。 最终目标是通过便宜的便携式平台对气体分子的强大检测和鉴定。 在我们过去的优势的基础上，三个相互关联的目标将集中精力朝着这些目标努力。 1）纳米力学系统的灵敏度将被推向最终极限。 2）将开发和利用一种新型的气体微通道系统，以最好地利用这种敏感性。 3）通过研究提供其他信息的部署（例如不同传感器涂层的阵列），将扩大纳米力学传感器的分析能力。 这些努力将进行，因为在实际化合物（例如疾病生物标志物）的气相色谱期间将纳米力学传感器与常规传感器进行了比较。 在此程序中创建的平台将在纳米机械，纳米力学，气相色谱和分析感测的领域产生直接影响。 预期的意义包括阐明光子学和纳米力学快速增长的组合场，新的气相色谱技术的发展，通过改进的气体分子识别的更好的检测限制，生物标志物分析的新方法以及无处不在的可及化学分析。 本科生和研究生将在独特的纳米制作，光子学，纳米力学，色谱和代谢组学专业知识以及分析和光电仪器的独特多学科环境中接受高水平的培训。