Nanomechanical gas chromatography for metabolite detection and breath analysis

用于代谢物检测和呼吸分析的纳米机械气相色谱

• 批准号: 356093-2013
• 负责人: Hiebert, Wayne
• 金额: $ 1.53万
• 依托单位: University of Alberta
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528029
• 关键词: Nanomechanical; gas; chromatography; metabolite; detection

Nanosensors continue to attract intense research attention for physical, chemical, and biological analysis due to intriguing properties like exceptional sensitivity and the promise of portability. Nanomechanical systems are one example: their surprising capability to weigh individual molecules has established their immense sensing potential. Gas chromatography is a very powerful analytical technique where broader portable adoption will benefit a wide swath of applications ranging from environmental monitoring to disease diagnosis. The main objective of this program is to incorporate nanomechanical sensing into gas chromatography to provide enhanced functionality. The ultimate goal is robust detection and identification of gas molecules by inexpensive portable platforms. Building on our past strengths, three interrelated objectives will focus our efforts in working towards these goals. 1) The sensitivity of nanomechanical systems will be pushed towards an ultimate limit. 2) A novel gas microchannel system will be developed and exploited to best take advantage of this sensitivity. 3) The analytical power of nanomechanical sensors will be broadened by studying deployments which provide additional information (such as arrays of different sensor coatings). These efforts will be carried out as the nanomechanical sensors are compared to regular sensors during gas chromatography of real compounds such as disease biomarkers. The platform created in this program will have immediate impacts in the fields of nanophotonics, nanomechanics, gas chromatography, and analytical sensing. The anticipated significance includes elucidation of the rapidly growing combined fields of photonics and nanomechanics, the development of a new gas chromatography technique, better limits of detection with improved gas molecule recognition, new methods for biomarker profiling, and ubiquitous accessible chemical analysis. Undergraduate and graduate students will be trained to a high level in a unique multi-disciplinary environment of nanofabrication, photonics, nanomechanics, chromatography, and metabolomics expertise and analytical and optoelectronic instrumentation.

纳米传感器继续吸引强烈的研究关注物理，化学和生物分析由于有趣的属性，如特殊的灵敏度和便携性的承诺。 纳米机械系统就是一个例子：它们令人惊讶的称量单个分子的能力建立了它们巨大的传感潜力。 气相色谱是一种非常强大的分析技术，更广泛的便携式采用将有利于从环境监测到疾病诊断的广泛应用。 该计划的主要目标是将纳米机械传感纳入气相色谱，以提供增强的功能。 最终目标是通过廉价的便携式平台对气体分子进行稳健的检测和识别。 在我们过去的优势基础上，三个相互关联的目标将集中我们努力实现这些目标。 1)纳米机械系统的灵敏度将被推向极限。 2)一种新型的气体微通道系统将被开发和利用，以最好地利用这种灵敏度。 3)纳米机械传感器的分析能力将通过研究提供额外信息的部署（例如不同传感器涂层的阵列）来扩大。 这些努力将在对真实的化合物（如疾病生物标志物）进行气相色谱分析时，将纳米机械传感器与常规传感器进行比较。 该计划中创建的平台将在纳米光子学，纳米力学，气相色谱和分析传感领域产生直接影响。 预期的意义包括阐明快速增长的光子学和纳米力学的结合领域，开发新的气相色谱技术，改进气体分子识别的更好的检测极限，生物标志物分析的新方法，以及无处不在的化学分析。 本科生和研究生将在纳米纤维，光子学，纳米力学，色谱和代谢组学专业知识以及分析和光电仪器的独特多学科环境中接受高水平的培训。