Optimization methods for total marrow irradiation using intensity modulated radiation therapy

调强放射治疗全骨髓照射的优化方法

• 批准号: 356144-2009
• 负责人: Aleman, Dionne
• 金额: $ 2.15万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528036
• 关键词: Optimization; methods; total; marrow; irradiation

It is estimated that over 4,500 new cases of leukemia and 7,900 new cases of lymphoma will be diagnosed in Canada in 2008 (Canadian Cancer Society, 2008). In the US, those numbers rise to 44,000 new cases of leukemia and 74,000 new cases of lymphoma (SEER Cancer Statistics Review, 1975-2005). A common treatment for these diseases, as well as many other diseases, is bone marrow transplantation. As part of a patient's preparation for a bone marrow transplant, the patient's existing bone marrow must be eradicated. This is typically achieved through a combination of chemotherapy and total marrow irradiation (TMI).

据估计，2008年加拿大将诊断出4，500多例白血病新病例和7，900例淋巴瘤新病例（Canadian Cancer Society，2008）。在美国，这些数字上升到44，000例新的白血病病例和74，000例新的淋巴瘤病例（SEER癌症统计评论，1975-2005）。这些疾病以及许多其他疾病的常见治疗方法是骨髓移植。作为患者骨髓移植准备工作的一部分，必须根除患者现有的骨髓。这通常通过化疗和全骨髓照射（TMI）的组合来实现。