Determining the genetic control of a dendritic cell subset

确定树突状细胞亚群的遗传控制

• 批准号: 371473-2009
• 负责人: Lesage, Sylvie
• 金额: $ 2.55万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528226
• 关键词: Determining; genetic; control; dendritic; cell

To clear pathogens and prevent infections, one must mount an efficient immune response. Dendritic cells are the most potent cell type for the initiation of effective responses to pathogens. In recent years, there has been a much accrued interest in the manipulation of dendritic cells for the development of new therapeutic protocols in cancer and autoimmunity. Moreover, the potential of using dendritic cell for vaccine development is currently being investigated. Fundamental research programs examining dendritic cells have led to the identification of various subsets. However, the specific role of each of these subsets remains to be resolved.

为了清除病原体和预防感染，必须建立有效的免疫反应。树突状细胞是启动对病原体的有效反应的最有效的细胞类型。近年来，人们对树突状细胞的操作产生了极大的兴趣，以开发癌症和自身免疫的新治疗方案。此外，目前正在研究使用树突状细胞进行疫苗开发的潜力。检查树突状细胞的基础研究项目已经导致了各种亚群的鉴定。然而，每个子集的具体作用仍有待解决。