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Synthesis and biosynthesis of polyketide natural products

Synthesis and biosynthesis of polyketide natural products
聚酮化合物天然产物的合成与生物合成
批准号:
371508-2009
负责人:
Boddy, Christopher
金额:
$2.91万
依托单位:
依托单位国家:
加拿大
项目类别:
Discovery Grants Program - Individual
财政年份:
2013
资助国家:
加拿大
项目状态:
已结题
起止时间:
2013-01-01 至 2014-12-31

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中文摘要
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英文摘要
Polyketide natural products are a major source of drugs to treat bacterial infections, and cancer. Developing efficient methods to synthesize these molecules and their analogs is necessary for understanding their mode of action, improving their pharmacological properties, and developing them as drugs. Polyketides are made by bacteria through modular, assembly line-like enzymatic pathways. It is possible to rationally reprogram these pathways to make new polyketides. This approach has the potential to revolutionize drug development and manufacturing, bringing new polyketide drugs to the market more rapidly with lower production costs.
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Harnessing synthesis and biosynthesis to access complex molecules
  • 批准号:
    RGPIN-2019-06859
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.66万
  • 财政年份:
    2022
  • 负责人:
    Boddy, Christopher
  • 依托单位:
Harnessing synthesis and biosynthesis to access complex molecules
  • 批准号:
    RGPIN-2019-06859
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.66万
  • 财政年份:
    2021
  • 负责人:
    Boddy, Christopher
  • 依托单位:
Harnessing synthesis and biosynthesis to access complex molecules
  • 批准号:
    RGPIN-2019-06859
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $4.66万
  • 财政年份:
    2020
  • 负责人:
    Boddy, Christopher
  • 依托单位:
Peptide synthesizer essential for natural products and chemical biology research
  • 批准号:
    RTI-2021-00791
  • 项目类别:
    Research Tools and Instruments
  • 资助金额:
    $6.32万
  • 财政年份:
    2020
  • 负责人:
    Boddy, Christopher
  • 依托单位:
国内基金
海外基金
中老年男性迟发性性腺功能障碍(LOH)分子生物学机制的研究
  • 批准号:
    30772285
  • 项目类别:
    面上项目
  • 资助金额:
    30.0万元
  • 批准年份:
    2007
  • 负责人:
    辛钟成
  • 依托单位: