MS detector to replace previous LCMS detector damaged in a catastrophic electrical fire

MS 检测器取代之前在灾难性电气火灾中损坏的 LCMS 检测器

• 批准号: RTI-2018-00455
• 负责人: Boddy, Christopher
• 金额: $ 10.93万
• 依托单位: University of Ottawa
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=642240
• 关键词: MS; detector; replace; previous; LCMS

We desperately require a replacement electrospray ionization mass spectrometer (MS) for our workhorse LC-MS system. LC-MS analysis is typically performed daily by each HQP in our research groups to detect and characterize complex molecules from biochemical reactions, bacterial cultivations, or in vivo metabolite trapping. Our previous MS detector experienced catastrophic failure (electrical fire), negatively impacting the training and progress through their degrees for all HQPs. No comparable instrument has sufficient availability or affordability to replace this essential research tool. Without this infrastructure, the Boddy lab will not be able to maintain its internationally recognized, cutting edge research program on harnessing natural product biosynthesis to access complex molecules nor will the Shuhendler lab be able to implement its revolutionary program for in vivo trapping of reactive drug metabolites.

我们迫切需要一个替代电喷雾电离质谱仪（MS）为我们的主力LC-MS系统。LC-MS分析通常由我们研究小组中的每个HQP每天进行，以检测和表征来自生化反应、细菌培养或体内代谢物捕获的复杂分子。我们之前的MS探测器经历了灾难性的故障（电气火灾），对所有HQP的培训和进度产生了负面影响。没有任何类似的工具有足够的可用性或可负担性来取代这一重要的研究工具。没有这个基础设施，Boddy实验室将无法维持其国际公认的尖端研究计划，利用天然产物生物合成来获取复杂分子，Shuhendler实验室也无法实施其革命性的体内捕获活性药物代谢物的计划。