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Biological effects of folate/cobalamin imbalance in mammals

叶酸/钴胺素失衡对哺乳动物的生物学影响

基本信息

批准号：
376200-2009
负责人：
Green, Timothy
金额：
$ 2.7万
依托单位：
University of British Columbia
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Group
财政年份：
2013
资助国家：
加拿大
起止时间：
2013-01-01 至 2014-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=528576
关键词：
Biological effects folate cobalamin imbalance

项目摘要

Folate is a vitamin required to make DNA and needed by all cells for growth and cell division. Folate requires another vitamin, cobalamin (vitamin B12), to function properly. Folic acid (man-made folate) is often added to animal feeds. In Canada and some other countries folic acid is also added to human foods to help prevent birth defects such as spina bifida. However, increasing folic acid content of the diet without increasing cobalamin may cause an imbalance in these vitamins. Our long-term goal is to study the biological effects of folate and cobalamin imbalance. We hypothesize that high folic acid / low cobalamin diets will change how genes (DNA) are expressed potentially leading to biological problems. To test this, we will determine in adult mice whether a high folic acid / low cobalamin diet alters how genes are expressed and whether this leads to problems in blood vessel function. We will also study whether exposing pregnant mice to a high folic acid / low cobalamin diet leads to changes in gene expression, increased fatness and impaired ability to process glucose in their offspring. Our research will help determine the best ratio of folic acid to cobalamin in the diet. It will also provide evidence as to the safety of increasing the amount of folic acid added to fortified foods and the possible need to add cobalamin.

叶酸是制造DNA所需的维生素，也是所有细胞生长和细胞分裂所需的维生素。叶酸需要另一种维生素，钴胺素（维生素B12），才能正常发挥作用。叶酸（人造叶酸）经常被添加到动物饲料中。在加拿大和其他一些国家，叶酸也被添加到人类食物中，以帮助预防出生缺陷，如脊柱裂。然而，增加饮食中叶酸的含量而不增加钴胺素可能会导致这些维生素的不平衡。我们的长期目标是研究叶酸和钴胺素失衡的生物学效应。我们假设高叶酸/低钴胺素饮食将改变基因（DNA）的表达方式，可能导致生物学问题。为了验证这一点，我们将在成年小鼠中确定高叶酸/低钴胺素饮食是否会改变基因的表达方式，以及这是否会导致血管功能的问题。我们还将研究将怀孕的小鼠暴露于高叶酸/低钴胺素饮食是否会导致基因表达的变化，肥胖增加和后代处理葡萄糖的能力受损。我们的研究将有助于确定饮食中叶酸与钴胺素的最佳比例。它还将提供证据，证明增加叶酸添加到强化食品中的安全性，以及可能需要添加钴胺素。