Coherent detection technology applied to biomedical imaging.

相干检测技术应用于生物医学成像。

• 批准号: 454250-2013
• 负责人: Kumar, Shiva
• 金额: $ 1.82万
• 依托单位: McMaster University
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2013
• 资助国家: 加拿大
• 起止时间: 2013-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=541764
• 关键词: Coherent; detection; technology; applied; biomedical

The imaging techniques based on stimulated Raman scattering (SRS) or coherent anti-Stokes Raman scattering (CARS) provide valuable and unique information pertaining to cellular and subcellular activities leading to the development of innovative methodologies for the early diagnosis and treatment of several diseases. These nonlinear imaging techniques have found diverse applications such as fast detection and identification of counterfeit medicines, and detection of chemical and biological hazardous materials. Typically, the intensity of the response signal is measured using a intensity detection receiver which ignores the phase. Here, it is proposed to use the coherent detection receiver which provides information on both intensity and phase of the response signal. Coherent detection provides the following benefits (i) the resolution of the image can be significantly increased due to the higher signal-to-noise ratio (SNR) provided by the mixing of the response

基于受激拉曼散射（SRS）或相干反斯托克斯拉曼散射（汽车）的成像技术提供了关于细胞和亚细胞活动的有价值的和独特的信息，从而导致开发用于早期诊断和治疗若干疾病的创新方法。这些非线性成像技术已经发现了多种应用，例如快速检测和识别假冒药品，以及检测化学和生物有害物质。通常，使用忽略相位的强度检测接收器来测量响应信号的强度。这里，建议使用相干检测接收器，其提供关于响应信号的强度和相位的信息。相干检测提供了以下益处：（i）由于响应的混合所提供的较高信噪比（SNR），图像的分辨率可以显著增加