Molecular biology and pathogenesis of fowl adenoviruses

禽腺病毒属于腺病毒科，与包涵体肝炎(IBH)等禽类疾病有关。然而，一些FAdv不是致病的，因此它们作为疫苗开发的病毒载体很有吸引力。为此，对这些病毒的基因操作旨在选择性地移除其遗传物质中的一些“可有可无”的区域，我已经确定了这些区域，然后用源自任何其他禽类(或其他)病原体的外来基因来替换它们。然而，FAdV基因组的“可有可无”区域在自然感染过程中的可能作用以及在疾病中的可能含义仍未被很好地了解。在人腺病毒中，它们的许多“可有可无的基因”在调节宿主的抗病毒防御方面非常重要。本研究的目的是鉴定FAdV左端可有区的独特基因，并确定其功能(S)，着重于发病机制。

Fowl adenoviruses (FAdVs) are in the family Adenoviridae, and are implicated in diseases of poultry such as inclusion body hepatitis (IBH). However, some FAdVs are not pathogenic and therefore they are attractive as viral vectors for vaccine development. For this purpose, genetic manipulation of these viruses is directed towards the selective removal of some "dispensable" regions of their genetic material, which I have already identified, followed by their replacement with foreign genes originating from any other avian (or other) pathogens. However the possible roles of the "dispensable" regions of FAdV genomes in the natural course of infection and the probable implications in disease are still not well understood. In human adenovirus many of their "dispensable genes" are very important in modulating the host's antiviral defense. This proposal is aimed to identify the FAdV unique genes in the dispensable region at the left end and to determine their function(s) with an emphasis on pathogenesis.