Fungal morphogenesis and environmental response

真菌形态发生和环境响应

• 批准号: 203696-2013
• 负责人: Kaminskyj, Susan
• 金额: $ 2.62万
• 依托单位: University of Saskatchewan
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=546391
• 关键词: Fungal; morphogenesis; environmental; response

Aspergillus, a mould, is an asexual fungus that impacts humanity for good and ill. Some species are used in biotechnology, but many are also opportunistic human pathogens causing morbid disease. Filamentous fungal cells, called hyphae, are surrounded, supported, and protected by cell walls that enable them to penetrate and explore their surroundings in search of nutrients. Hyphae are tubular and grow only at their tips, where they secrete wall-forming materials. The hyphal wall forms a porous interface between the cell and its environment. Wall composition, structure and function are inter-dependent. As in all fungi, the Aspergillus wall is ~85% carbohydrate, mostly types not found in animals. Wall biosynthesis pathways can be anti-fungal drug targets.

曲霉，一种霉菌，是一种无性真菌，对人类有好有坏的影响。一些物种被用于生物技术，但许多物种也是导致病态疾病的投机的人类病原体。丝状真菌细胞，称为菌丝，由细胞壁包围、支撑和保护，使它们能够穿透并探索周围环境以寻找营养。菌丝是管状的，只在其顶端生长，在那里它们分泌形成壁的物质。菌丝壁在细胞和环境之间形成了一个多孔的界面。墙体的组成、结构和功能是相互依存的。与所有真菌一样，曲霉菌壁含有约85%的碳水化合物，大多数类型在动物中找不到。WALL生物合成途径可以成为抗真菌药物的靶点。