Evo-neuro and the evolution of fast neurotransmission

Evo-neuro 和快速神经传递的进化

• 批准号: 227828-2010
• 负责人: Dent, Joseph
• 金额: $ 1.97万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=546838
• 关键词: Evo; neuro; evolution; fast; neurotransmission

Animal nervous systems are the most complex, computationally powerful objects in the known universe. To explain how that complexity arose as a result of changes at the molecular level is a major challenge for the theory of Darwinian evolution. Only recently, with the availability of multiple diverse metazoan genome sequences and a growing understanding of the function of key nervous system proteins, have we been able to take initial steps towards a description of how the molecular parts that make up the nervous system came to be. I propose to exploit these resources to begin to develop a model of when and how the ion channel neurotransmitter receptors that are central to fast neurotransmission in all metazoa evolved.

动物的神经系统是已知宇宙中最复杂、计算能力最强的物体。要解释这种复杂性是如何从分子水平的变化中产生的，是对达尔文进化论的一个重大挑战。直到最近，随着多种多样的后生动物基因组序列的可用性和对关键神经系统蛋白质功能的日益了解，我们才能够迈出初步的步骤，描述构成神经系统的分子部分是如何形成的。我建议利用这些资源，开始建立一个模型，说明在所有后生动物中，离子通道神经递质受体是快速神经传递的核心，它是何时以及如何进化的。