Characterization of the Neuroinflammation in Autosomal Dominant Alzheimer Disease Using Neuro-Inflammation Imaging
使用神经炎症成像表征常染色体显性阿尔茨海默病的神经炎症
基本信息
- 批准号:10196311
- 负责人:
- 金额:$ 15.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2023-03-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease diagnosisAlzheimer&aposs disease patientAlzheimer&aposs disease testAmyloidAmyloid beta-ProteinAmyloid depositionAnimal ModelBiologicalBiological MarkersBrainBrain regionCell DensityCell SizeCellsClinicalClinical TrialsComputer SimulationDataDevelopmentDiffuseDiffusionDiffusion Magnetic Resonance ImagingDiseaseDisease ProgressionEdemaEvolutionFreezingGoalsHistologyImageImaging TechniquesImmuneImmune systemImpaired cognitionInfiltrationInflammationInfrastructureInheritedMeasuresMediatingMissionNeurofibrillary TanglesOutcomeParticipantPathogenesisPathologicPositioning AttributePositron-Emission TomographyPrevalenceProcessPrognosisProtocols documentationReproducibilityResearchRoleSpatial DistributionSurrogate MarkersSymptomsTauopathiesTestingTracerWaterautosomal dominant Alzheimer&aposs diseasebasecellular imagingcohortcostextracellulargray matterhuman tissueimmune activationimprovedindexinginterestmutation carrierneuroinflammationnon-invasive imagingnovelpre-clinicalquantitative imagingresearch and developmentsuccesstau Proteinstherapy developmentvascular risk factorwhite matter
项目摘要
PROJECT SUMMARY/ABSTRACT
Mounting evidence shows that immune system-mediated actions and neuroinflammation may
contribute as much (or more) to Alzheimer disease (AD) pathogenesis as beta-amyloid and
neurofibrillary tangle markers. Reliable, safe, and readily repeatable neuroinflammation tests
during disease development have brought significant challenges in mechanistic research and
therapy development. To address this unmet need, we developed neuro-inflammation
imaging (NII), a quantitative imaging solution for neuroinflammation test. Based on diffusion
magnetic resonance imaging (MRI), NII allows us to non-invasively, non-radioactively
characterize the spatial distribution and temporal progression of neuroinflammation. The
primary goal of this project is to cost-effectively characterize the role of neuroinflammation in
AD using NII by retrospectively analyzing previously collected diffusion MRI data from the
unique autosomal-dominant Alzheimer's disease (ADAD) cohort. Even though a relatively small
proportion of cases of AD, ADAD present the similar pathological features to sporadic AD, has a
predictable age at onset and low vascular risk factors due to the young age of the cohort, which
makes the cohort very unique to determine the temporal evolution of neuroinflammation that
culminates in AD. In this project, the trajectory of NII neuroinflammation biomarkers during the
natural course of ADAD will be characterized and determined. The associations between whole-
brain NII neuroinflammation biomarkers and CSF inflammation measures (sTREM2 and YKL40)
will be examined. And the relationships among neuroinflammation measured by NII, amyloid
deposition, and tauopathy measured by PET tracers will also be assessed. The successful
retrospective analysis of previously collected diffusion MRI data in ADAD using NII will
significantly enhance our understanding of the role of neuroinflammation in the initiation and
progression of AD. The integration of NII neuroinflammation biomarkers into the DIAN and other
clinical trial studies will provide neuroinflammation surrogate biomarkers complementary to
other pathological measures for better AD diagnosis, prognosis, and treatment.
项目总结/摘要
越来越多的证据表明,免疫系统介导的作用和神经炎症可能
与β-淀粉样蛋白一样(或更多)对阿尔茨海默病(AD)发病机制的贡献,
神经缠结标记。可靠、安全且易于重复的神经炎症试验
在疾病发展过程中,给机制研究带来了重大挑战,
治疗发展。为了解决这一未满足的需求,我们开发了神经炎症
成像(NII),用于神经炎症测试的定量成像解决方案。基于扩散
磁共振成像(MRI),NII允许我们非侵入性,非放射性
表征神经炎症的空间分布和时间进展。的
该项目的主要目标是经济有效地描述神经炎症在
通过回顾性分析先前收集的来自NII的扩散MRI数据,
独特的常染色体显性阿尔茨海默病(ADAD)队列。虽然相对较小,
AD的病例比例,ADAD呈现与散发性AD相似的病理特征,
可预测的发病年龄和低血管风险因素,由于队列的年轻,
使得该队列在确定神经炎症的时间演变方面非常独特,
在AD中达到高潮。在这个项目中,NII神经炎症生物标志物的轨迹,
ADAD的自然过程将被表征和确定。整体之间的联系-
脑NII神经炎症生物标志物和CSF炎症测量(sTREM 2和YKL 40)
将被审查。以及NII、淀粉样蛋白、
还将评估通过PET示踪剂测量的tau蛋白沉积和tau蛋白病。成功
回顾性分析先前使用NII收集的ADAD弥散MRI数据,
显著增强了我们对神经炎症在启动和
AD的进展。将NII神经炎症生物标志物整合到DIAN和其他
临床试验研究将提供神经炎症替代生物标志物,
其他病理学指标用于更好的AD诊断、预后和治疗。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
QING WANG其他文献
QING WANG的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('QING WANG', 18)}}的其他基金
Quantitative Endogenous MRI Imaging of Neuroinflammation in AD
AD 神经炎症的定量内源 MRI 成像
- 批准号:
10334974 - 财政年份:2022
- 资助金额:
$ 15.75万 - 项目类别:
Quantitative Endogenous MRI Imaging of Neuroinflammation in AD
AD 神经炎症的定量内源 MRI 成像
- 批准号:
10596110 - 财政年份:2022
- 资助金额:
$ 15.75万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Continuing Grant
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Fellowship
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
- 批准号:
24K13490 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
- 批准号:
EP/Z00022X/1 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
- 批准号:
MR/Y003365/1 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
- 批准号:
AH/Y007549/1 - 财政年份:2024
- 资助金额:
$ 15.75万 - 项目类别:
Research Grant