Structural bioinorganics

结构生物无机物

• 批准号: 312809-2011
• 负责人: Barralet, Jake
• 金额: $ 2.91万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548832
• 关键词: Structural; bioinorganics

The localised delivery of bioinorganics for tissue repair has come about through serendipitous findings in degradable biomaterials studies and now a tremendous opportunity exists to link bioinorganics and biomaterials, to create what I term 'structural bioinorganics'. These being biomaterials that exert a desirable biological response by the release of inorganic (non-carbon) ions or molecules from which they are made. They thereby serve a dual function having structural integrity and bioactivity. Engineering has performed well in restoring mechanical function of joints and valves with prostheses, but has been less impressive in the field of regeneration where understanding of several disciplines is required to make progress. Bone is perhaps the area where most promise lies due to its inherent limited regenerative capacity. Until recently researchers had thought that recombinant bone morphogenic protein products were the 'magic bullet' for bone regeneration, however there have been a number of reports of complications and even death following and a recognition that they are at best as good as bone autograft and significantly more expensive. For this reason there is renewed interest in finding non-protein based regenerative approaches that can offer patients and health providers a cost effective improvement on the current situation of bone harvesting surgery prior to grafting. Furthermore, principles or wound repair are largely similar, requiring angiogenesis, initial tissue deposition followed by remodelling, and progress on enhancing the initial stages of tissue healing can be applied to other tissues. Using osteoconductive cements and nanostructured particulates as model hosts for bioinorganics the applicant seeks to explore the potential for stimulation of bone healing by compounds with which his laboratory has made important recent new preliminary findings, or has unique insight as well as compounds known in the literature which are linked to stimulating bone healing but as yet are not utilised.

用于组织修复的生物无机物的局部递送是通过可降解生物材料研究中的偶然发现而实现的，现在存在将生物无机物和生物材料联系起来的巨大机会，以创建我所说的“结构生物无机物”。 这些生物材料通过释放无机（非碳）离子或分子来发挥所需的生物反应。 因此，它们具有结构完整性和生物活性的双重功能。 工程学在利用假体恢复关节和瓣膜的机械功能方面表现良好，但在再生领域却表现不佳，因为再生领域需要了解多个学科才能取得进展。 由于其固有的有限再生能力，骨骼可能是最有希望的领域。 直到最近，研究人员还认为重组骨形态发生蛋白产品是骨再生的“灵丹妙药”，然而，已经有许多关于并发症甚至死亡的报道，并认识到它们充其量与自体骨移植一样好，而且价格昂贵得多。 因此，人们对寻找基于非蛋白质的再生方法重新产生了兴趣，这些方法可以为患者和医疗服务提供者提供对移植前骨采集手术现状的成本有效的改善。 此外，伤口修复的原理在很大程度上相似，需要血管生成、初始组织沉积和重塑，并且增强组织愈合初始阶段的进展可以应用于其他组织。 使用骨传导水泥和纳米结构颗粒作为生物无机物的模型宿主，申请人试图探索其实验室最近取得重要新初步发现的化合物刺激骨愈合的潜力，或者具有独特的见解以及文献中已知的与刺激骨愈合有关但尚未使用的化合物。