Models of vessel calcification

矿化斑块导致的脉管系统完全闭塞极难治疗，并且妨碍了常规用于恢复狭窄血管血流的支架的使用。该Engage提案的合作伙伴 ** 拥有革命性的CE认证冲击波技术，可以安全地刺穿钙化梗阻，从而实现 ** 传统支架植入术。然后，这项技术可以消除对冠状动脉和外周血管搭桥术的需求 **，从而大大改善许多患有冠状动脉疾病的患者的生活质量。为了研究第二代和第三代产品，拥有钙化血管的模型将具有很大的价值，因为目前只有患病的人体组织和来自疾病模型的一些动物血管可用。显然，围绕供体人体组织的使用存在实际问题，** 动脉粥样硬化的动物模型需要相当长的时间来开发。** PI熟悉多种天然和合成 ** 聚合物诱导快速矿化的技术，并将确定从已死亡动物 ** 中采集的股动脉快速矿化的途径，以模拟人类疾病。这将为Soundbite Medical提供一种工具来筛选其硬件的各种配置，从而加速为这些患者开发更好的工具。

Complete occlusion of the vasculature by mineralised plaques is extremely difficult to treat and prevents the**use of stents that are routinely used to restore flow to narrowed vessels. The partner of this Engage proposal**has a revolutionary CE marked shockwave technology that can safely pierce the calcified obstruction enabling**traditional stenting. This technology then can erradicate the need for some coronary and peripheral bypasses**thereby vastly improving quality of life for many patients with criovascular disease.**In order to work on second and third generation products, having a model of calcified vessels will be of great**value since currently only diseased human tissues and some animal vessels from models of diseases are**available. Clearly there are practical issues surrounding the use of donor human tissues and animal models of**atherosclerosis require considerable time to develop.**The PI is familiar with several techniqes to induce rapid mineralisaton is a variety of natural and synthetic**polymers and will identify routes to rapidly mineralizing femoral arteries harvested from already dead animals**to produce mimics of the human diseased condition. This will afford Soundbite Medical a tool to screen**various configurations of their hardware, thereby accelerating devlopment of better tools for these patients.