Models of vessel calcification

矿化斑块导致的血管完全闭塞非常难以治疗，这阻碍了常规用于恢复狭窄血管血流的支架的使用。Engage提案的合作伙伴**拥有革命性的CE标志冲击波技术，可以安全地穿透钙化的阻塞，从而实现传统的支架置入。这项技术可以消除一些冠状动脉和外周绕道手术的需要，从而极大地提高了许多心血管疾病患者的生活质量。**由于目前只有患病的人体组织和一些疾病模型的动物血管**可用，因此为了开发第二代和第三代产品，拥有钙化血管模型将具有很大的**价值。显然，在使用供体人体组织和动物动脉粥样硬化模型方面存在实际问题，需要相当长的时间来开发。** PI熟悉几种技术来诱导各种天然和合成聚合物的快速矿化，并将确定从已经死亡的动物身上获取的快速矿化股动脉的途径**，以产生人类疾病状况的模拟物。这将提供一种工具来筛选他们硬件的各种配置，从而加速为这些患者开发更好的工具。

Complete occlusion of the vasculature by mineralised plaques is extremely difficult to treat and prevents the**use of stents that are routinely used to restore flow to narrowed vessels. The partner of this Engage proposal**has a revolutionary CE marked shockwave technology that can safely pierce the calcified obstruction enabling**traditional stenting. This technology then can erradicate the need for some coronary and peripheral bypasses**thereby vastly improving quality of life for many patients with criovascular disease.**In order to work on second and third generation products, having a model of calcified vessels will be of great**value since currently only diseased human tissues and some animal vessels from models of diseases are**available. Clearly there are practical issues surrounding the use of donor human tissues and animal models of**atherosclerosis require considerable time to develop.**The PI is familiar with several techniqes to induce rapid mineralisaton is a variety of natural and synthetic**polymers and will identify routes to rapidly mineralizing femoral arteries harvested from already dead animals**to produce mimics of the human diseased condition. This will afford Soundbite Medical a tool to screen**various configurations of their hardware, thereby accelerating devlopment of better tools for these patients.