Models of vessel calcification

矿化斑块对脉管系统的完全闭塞极其难以治疗，并且妨碍了通常用于恢复狭窄血管血流的支架的使用。此 Engage 提案的合作伙伴**拥有革命性的 CE 标记冲击波技术，可以安全地刺穿钙化阻塞，从而实现**传统支架置入术。这项技术可以消除对一些冠状动脉和外周搭桥术的需求**，从而极大地提高许多患有心血管疾病的患者的生活质量。**为了开发第二代和第三代产品，拥有钙化血管模型将具有巨大的**价值，因为目前只有患病的人体组织和来自疾病模型的一些动物血管**可用。显然，使用供体人体组织和**动脉粥样硬化动物模型需要相当长的时间来开发，存在实际问题。**PI熟悉多种诱导快速矿化的技术，包括各种天然和合成**聚合物，并将确定快速矿化从已死亡动物**获取的股动脉的途径，以产生人类患病状况的模拟物。这将为 Soundbite Medical 提供一个工具来筛选**各种硬件配置，从而加速为这些患者开发更好的工具。

Complete occlusion of the vasculature by mineralised plaques is extremely difficult to treat and prevents the**use of stents that are routinely used to restore flow to narrowed vessels. The partner of this Engage proposal**has a revolutionary CE marked shockwave technology that can safely pierce the calcified obstruction enabling**traditional stenting. This technology then can erradicate the need for some coronary and peripheral bypasses**thereby vastly improving quality of life for many patients with criovascular disease.**In order to work on second and third generation products, having a model of calcified vessels will be of great**value since currently only diseased human tissues and some animal vessels from models of diseases are**available. Clearly there are practical issues surrounding the use of donor human tissues and animal models of**atherosclerosis require considerable time to develop.**The PI is familiar with several techniqes to induce rapid mineralisaton is a variety of natural and synthetic**polymers and will identify routes to rapidly mineralizing femoral arteries harvested from already dead animals**to produce mimics of the human diseased condition. This will afford Soundbite Medical a tool to screen**various configurations of their hardware, thereby accelerating devlopment of better tools for these patients.