Structural bioinorganics

在可降解生物材料的研究中，偶然发现了用于组织修复的生物无机物的局部递送，现在存在着将生物无机物和生物材料联系起来的巨大机会，以创造我所说的“结构生物无机物”。这些是生物材料，通过释放无机（非碳）离子或分子来发挥理想的生物反应。因此，它们具有结构完整性和生物活性的双重功能。工程在修复关节和瓣膜的机械功能方面表现良好，但在再生领域却不那么令人印象深刻，因为这需要对几个学科的理解才能取得进展。骨可能是最有希望的领域，因为它固有的有限的再生能力。直到最近，研究人员一直认为重组骨形态发生蛋白产品是骨再生的“神奇子弹”，然而，已经有许多并发症甚至死亡的报道，并且认识到它们充其量与自体骨移植一样好，而且要贵得多。由于这个原因，人们对寻找非蛋白的再生方法重新产生了兴趣，这种方法可以为患者和健康提供者提供成本有效的改进，以改善移植前的骨采集手术的现状。此外，伤口修复的原理在很大程度上是相似的，需要血管生成，最初的组织沉积，然后是重塑，并且在增强组织愈合的初始阶段的进展可以应用于其他组织。使用骨传导水泥和纳米结构颗粒作为生物无机物的模型宿主，申请人试图探索化合物刺激骨愈合的潜力，他的实验室最近取得了重要的新的初步发现，或者具有独特的见解，以及文献中已知的与刺激骨愈合有关但尚未使用的化合物。

The localised delivery of bioinorganics for tissue repair has come about through serendipitous findings in degradable biomaterials studies and now a tremendous opportunity exists to link bioinorganics and biomaterials, to create what I term 'structural bioinorganics'. These being biomaterials that exert a desirable biological response by the release of inorganic (non-carbon) ions or molecules from which they are made. They thereby serve a dual function having structural integrity and bioactivity. Engineering has performed well in restoring mechanical function of joints and valves with prostheses, but has been less impressive in the field of regeneration where understanding of several disciplines is required to make progress. Bone is perhaps the area where most promise lies due to its inherent limited regenerative capacity. Until recently researchers had thought that recombinant bone morphogenic protein products were the 'magic bullet' for bone regeneration, however there have been a number of reports of complications and even death following and a recognition that they are at best as good as bone autograft and significantly more expensive. For this reason there is renewed interest in finding non-protein based regenerative approaches that can offer patients and health providers a cost effective improvement on the current situation of bone harvesting surgery prior to grafting. Furthermore, principles or wound repair are largely similar, requiring angiogenesis, initial tissue deposition followed by remodelling, and progress on enhancing the initial stages of tissue healing can be applied to other tissues. Using osteoconductive cements and nanostructured particulates as model hosts for bioinorganics the applicant seeks to explore the potential for stimulation of bone healing by compounds with which his laboratory has made important recent new preliminary findings, or has unique insight as well as compounds known in the literature which are linked to stimulating bone healing but as yet are not utilised.