Self Sustaining Scaffolds

自持式脚手架

• 批准号: RGPIN-2017-06829
• 负责人: Barralet, Jake
• 金额: $ 2.04万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=638103
• 关键词: Self; Sustaining; Scaffolds

Globally, millions of people die, undergo amputation or suffer loss of function because some of the estimated 2-50 billion capillaries in their bodies cease to function normally. Recent advances in stenting, surgery and phamaceutics have helped bypass, open and prevent closure of small diameter arteries saving countless lives. At or below the scale of arterioles - venules the vasculature can regenerate rapidly but science has little understanding of how to purposefully direct or enhance this innate power to induce augmented regeneration. Patients simply wait for adequate healing to occur and avoid infection. Poor healing due to advanced age, diabetes and vascular disease, leads to complications such as increased post surgical mortality, failure of interventions and prolonged hospital stays. State of the art is a simple vacuum dressing that can stop fluid build up, help reduce infection and thereby accelerate healing or where feasible a hyperbaric oxygen chamber. It occurred to the applicant that the huge effort in improving oxygen diffusion into and waste out of porous electrodes to build the fuel cell powered future could also be applied to devices that could potentially replicate some of the functions of capillaries. Preliminary data with sustained oxygen delivery peroxide decomposition composites were highly encouraging such as preventing necrosis and loss of tissue in a poorly vascularized wound, maintaining avascular tissue viability long enough for revasuclarisation of a 17mm thick graft, culturing cells for 3 days at hitherto impossible densities: (1.5mm diameter spheres, density 2 x10

在全球范围内，数以百万计的人死亡、截肢或功能丧失，因为他们体内估计有20 - 500亿根毛细血管中的一些停止了正常功能。支架置入术、外科手术和药物的最新进展已经帮助小直径动脉搭桥、打开和防止关闭，挽救了无数人的生命。在小动脉或小静脉的范围内，血管系统可以迅速再生，但科学对如何有目的地指导或增强这种天生的力量来诱导增强再生知之甚少。患者只需等待足够的愈合发生并避免感染。老年、糖尿病和血管疾病导致的愈合不良导致手术后死亡率增加、干预措施失败和住院时间延长等并发症。最先进的技术是一种简单的真空敷料，可以阻止液体积聚，帮助减少感染，从而加速愈合，或者在可行的情况下使用高压氧舱。申请人突然想到，为了构建燃料电池供电的未来，在改善氧气进入和排出多孔电极方面所做的巨大努力，也可以应用于可能复制毛细血管某些功能的设备。持续供氧过氧化分解复合材料的初步数据非常令人鼓舞，例如防止血管化不良伤口的坏死和组织损失，维持无血管组织活力足够长时间以进行17mm厚移植物的血管重建，在迄今为止不可能的密度下培养细胞3天：（直径1.5mm的球体，密度2 × 10）