Nutraceutical properties of chlorogenic acid

咖啡是世界上消费最广泛的饮料之一，也是现代饮食中抗氧化剂的主要来源。有鉴于此，人们对咖啡的生理效应的兴趣激增，因为实验和临床研究都报告了令人兴奋的营养潜力。对本应用特别感兴趣的是咖啡消费对葡萄糖稳态的影响。尽管有令人信服的流行病学证据，但咖啡中特定的成分(S)和咖啡对血糖稳态的影响的生理机制尚不清楚。由于咖啡因，无论是单独摄入还是作为咖啡的一部分摄入，都会严重削弱胰岛素敏感性，咖啡中除咖啡因之外的其他成分可能是原因之一。绿原酸(CGA)是煮咖啡中的主要抗氧化剂。摄入后，少量的CGA从胃和小肠原封不动地被吸收，其余的在结肠中进行水解和随后的代谢物吸收。总体假设是，CGA对咖啡对血糖稳态的有益影响负有责任。为了深入了解CGA在正常生理和病理生理中对全身和组织的特定作用，我们将采用体内动物模型。

Coffee is one of the world's most widely consumed beverages and the primary source of antioxidants in the modern diet. Given this, interest in the physiological effects of coffee has exploded as both experimental and clinical investigations report exciting nutraceutical potential. Of particular interest to the present application is the impact of coffee consumption on glucose homeostasis. Despite convincing epidemiological evidence, the specific coffee component(s) and physiological mechanisms responsible for the effects of coffee on glucose homeostasis are unclear. As caffeine, either ingested alone or as a part of coffee, acutely impairs insulin sensitivity, a component of coffee other than caffeine is likely responsible. Chlorogenic acids (CGA) are the main antioxidants in brewed coffee. Upon ingestion, small amounts of CGA are absorbed intact from the stomach and small intestine, with the remainder undergoing hydrolysis and subsequent absorption of the metabolites in the colon. The overall hypothesis is that CGA is responsible for the beneficial effects of coffee on glucose homeostasis. To gain insight into whole body and tissue specific effects of CGA in normal and pathological physiology, an in vivo animal model will be employed.