Gut Based Modulators of Metabolism

基于肠道的代谢调节剂

• 批准号: RGPIN-2017-04139
• 负责人: Shearer, Jane
• 金额: $ 2.04万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=631032
• 关键词: Gut; Based; Modulators; Metabolism

Despite an abundance of evidence showing the gut microbiome to influence metabolism, our understanding of the mechanisms by which differential gut microbiota contribute to metabolism is incomplete. In this respect, recent studies have revealed that the host and the microbiota are involved in several complex interactions resulting in so-called “host-microbiome metabolic axes”. These metabolic axes result in the combinatorial metabolism of substrates by the microbiome and host genome, exemplified by the production of bile acids, choline

尽管有大量的证据表明肠道微生物群可以影响新陈代谢，但我们对肠道微生物区系差异对新陈代谢的影响机制的了解还不完全。在这方面，最近的研究表明，宿主和微生物群参与了几个复杂的相互作用，导致了所谓的“宿主-微生物组代谢轴”。这些代谢轴导致微生物组和宿主基因组对底物的组合代谢，例如胆汁酸、胆碱的产生。