Exploring cortico-striatal connectivity across different domains of cognition combining TMS and fMRI

结合 TMS 和 fMRI 探索不同认知领域的皮质纹状体连接

• 批准号: 327518-2011
• 负责人: Monchi, Oury
• 金额: $ 2.62万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549108
• 关键词: Exploring; cortico; striatal; connectivity; across

Together, the frontal portion and the deep nuclei of the brain are involved in the control of movement as well as mental processes such as making decisions. These structures are often affected in different neurological and psychiatric disorders, including Parkinson's disease and schizophrenia. Our laboratory has developed tasks to tease apart the role of individual structures in these regions, using techniques such as functional magnetic resonance imaging (MRI). In particular, we were able to separate the functions of two sub-regions of the frontal lobe and the caudate nucleus (a deep structure of the brain) that are involved in executive processes. We have also developed tasks to distinguish the function of a more posterior region of the frontal lobe and the putamen, another deep brain structure, in the execution of movements.

大脑的额叶部分和深层核团共同参与运动的控制以及决策等心理过程。这些结构经常受到不同神经和精神疾病的影响，包括帕金森病和精神分裂症。我们的实验室已经开发了一些任务，利用功能性磁共振成像 (MRI) 等技术来梳理这些区域中各个结构的作用。特别是，我们能够区分参与执行过程的额叶和尾状核（大脑的深层结构）两个子区域的功能。我们还开发了一些任务来区分额叶后部区域和壳核（另一种深层大脑结构）在执行运动时的功能。