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Heart valve cell and matrix biomechanics and mechanobiology

Heart valve cell and matrix biomechanics and mechanobiology
心脏瓣膜细胞和基质生物力学和力学生物学
批准号：
327627-2011
负责人：
Simmons, Craig
金额：
$2.33万
依托单位：
University of Toronto
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-01-01 至 2015-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=549146
关键词：
Heartvalvecellmatrixbiomechanics

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英文摘要
Diseases of the heart valves are among the most frequent causes of heart disease in Canada. Currently, there is no medicine available to treat valve disease. This is because little is known about the cells and molecules that initiate and drive the disease. Importantly, valves become diseased in regions subjected to specific mechanical forces, suggesting that mechanical forces cause the cells locally in these regions to change from healthy to diseased. In order to study how this occurs (and therefore hopefully identify therapeutic targets), we required a deeper understanding of how forces at the level of the whole valve get transferred to the cells within the valve tissue to regulate their function.
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