Lower Vertebrate Immunostimulation and effects on host-parasite interactions

低等脊椎动物的免疫刺激及其对宿主-寄生虫相互作用的影响

• 批准号: 402288-2012
• 负责人: Fast, Mark
• 金额: $ 1.89万
• 依托单位: University of Prince Edward Island
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550857
• 关键词: Lower; Vertebrate; Immunostimulation; effects; host

Atlantic salmon farming contributes over $600 million annually to the Canadian economy. The industry is controversial due to the perceived damage it causes to the environment, in part, through the spread of sea lice, Lepeophtheirus salmonis infections to wild stocks. Losses to Canadian industry, attributed to L. salmonis infection and the associated cost of chemotherapeutic treatment, have been estimated at more than $50 million/yr. Therefore, sea lice infection in farmed salmon is both an important environmental and economic issue, especially within coastal communities and First Nations. Over the last two decades only a handful of different treatments against sea lice have been available, the most effective treatment, through the early part of the new millennium, was an in-feed treatment called SLICETM (Schering-Plough), which now has exhibited inefficacy due to resistance by sea lice in numerous countries over the past couple years. Any new treatment regime, vaccine or immunostimulant that can provide significant protection, would have immediate economic impact and improve Canadian salmon farming industry efficiency of production and sustainability.

大西洋鲑鱼养殖每年为加拿大经济贡献6亿多加元。 该行业是有争议的，因为它对环境造成的损害，部分是通过传播海虱，鲑鱼麻风病感染野生种群。 加拿大工业的损失，归因于L。沙门氏菌感染和化疗治疗的相关费用估计超过5000万美元/年。 因此，养殖鲑鱼中的海虱感染是一个重要的环境和经济问题，特别是在沿海社区和原住民中。在过去的二十年里，只有少数不同的针对海虱的治疗方法可用，在新千年初期，最有效的治疗方法是一种名为SLICETM（先灵葆雅）的饲料中治疗，该治疗方法现在已经表现出无效。由于过去几年许多国家的海虱产生了耐药性。任何新的治疗方案，疫苗或免疫刺激剂，可以提供显着的保护，将有直接的经济影响，并提高加拿大鲑鱼养殖业的生产效率和可持续性。