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Defining the Molecular Mechanisms and Clinical Implications of p66ShcA as a Driver of the Epithelial to Mesenchymal Transition in Breast Cancer

Defining the Molecular Mechanisms and Clinical Implications of p66ShcA as a Driver of the Epithelial to Mesenchymal Transition in Breast Cancer
定义 p66ShcA 作为乳腺癌上皮间质转化驱动因素的分子机制和临床意义
批准号：
291181
负责人：
Ursini-Siegel Giuseppina
金额：
$49.94万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2013
资助国家：
加拿大
项目状态：
已结题
起止时间：
2013-09-01 至 2018-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=291181&lang=en
关键词：
Basal Subtype Breast Cancer Epithelial To Mesenchymal Transition Luminal Subtype Met Metastasis P66shca Reactive Oxygen Species Signal Transduction Transgenic Mice

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Breast cancers are molecularly distinct and include at least five specific subtypes each having unique clinical outcomes. Breast tumors that stratify within the luminal subtypes are generally considered as good outcome, although a subset of women with lu
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