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Defining the mechanisms and therapeutic potential of ShcA-mediated angiogenesis and metabolism that fuel breast tumorigenesis

Defining the mechanisms and therapeutic potential of ShcA-mediated angiogenesis and metabolism that fuel breast tumorigenesis
定义促进乳腺肿瘤发生的 ShcA 介导的血管生成和代谢的机制和治疗潜力
批准号：
321218
负责人：
Ursini-Siegel Giuseppina
金额：
$59.57万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2015
资助国家：
加拿大
项目状态：
已结题
起止时间：
2015-03-01 至 2020-03-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=321218&lang=en
关键词：
Akt/Mtor Angiogenesis Breast Cancer Breast Cancer Cell Lines/Pdx Metformin Shca Signal Transduction Transgenic Mice Tumor Metabolism

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英文摘要
Cancer cells grow uncontrollably and are unresponsive to the checkpoints that restrain the growth of normal cells. In order to support such rapid proliferation, cancer cells must substantially increase their ability to acquire nutrients and oxygen by gene
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Inducing oxidative stress as a mechanism to increase the clinical impact of complex I inhibitors in treating aggressive breast cancers.
Capitalizing on an oxidative stress response to sensitize poor outcome cancers to PARP inhibitors
Understanding how oxidative stress influences tumor evolution via metabolic reprogramming
Defining the Molecular Mechanisms and Clinical Implications of p66ShcA as a Driver of the Epithelial to Mesenchymal Transition in Breast Cancer
国内基金
海外基金
ROBO4对视网膜血管生成(angiogenesis)的调控及其分子机制
  • 批准号：
    81200692
  • 项目类别：
    青年科学基金项目
  • 资助金额：
    23.0万元
  • 批准年份：
    2012
  • 负责人：
    陈凌
  • 依托单位：
    同济大学