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Inducing oxidative stress as a mechanism to increase the clinical impact of complex I inhibitors in treating aggressive breast cancers.

Inducing oxidative stress as a mechanism to increase the clinical impact of complex I inhibitors in treating aggressive breast cancers.
诱导氧化应激作为增加复合物 I 抑制剂治疗侵袭性乳腺癌临床影响的机制。
批准号：
455845
负责人：
Ursini-Siegel Giuseppina
金额：
$7.29万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-09-01 至 2022-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=455845&lang=en
关键词：
Breast Cancer Complex I Inhibitor Oxidative Stress Patient Derived Xenografts Pre-Clinical Models Ros Scavengers Targeted Therapies Tumor Metabolism

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英文摘要
Despite significant improvements in our ability to treat some breast cancers, a significant subset of women retain a poor likelihood of survival when diagnosed with this disease. This is especially true for women who develop more aggressive breast cancer
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