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Capitalizing on an oxidative stress response to sensitize poor outcome cancers to PARP inhibitors

Capitalizing on an oxidative stress response to sensitize poor outcome cancers to PARP inhibitors
利用氧化应激反应使预后不良的癌症对 PARP 抑制剂敏感
批准号：
408071
负责人：
Ursini-Siegel Giuseppina
金额：
$69.11万
依托单位：
Lady Davis Institute for Medical Research (Mtl)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2019
资助国家：
加拿大
项目状态：
已结题
起止时间：
2019-09-01 至 2024-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=408071&lang=en
关键词：
Chemotherapy Mouse Models Oxidative Stress P66shca Parp Inhibitors Patient Derived Xenograft

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英文摘要
Breast cancer accounts for ~25% of all diagnosed malignancies in women and is second only to lung cancer in cancer associated deaths. TNBC is the most aggressive form of this disease, representing 15% of breast cancer cases, equating to ~3500 new diagnose
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Inducing oxidative stress as a mechanism to increase the clinical impact of complex I inhibitors in treating aggressive breast cancers.
Understanding how oxidative stress influences tumor evolution via metabolic reprogramming
Defining the mechanisms and therapeutic potential of ShcA-mediated angiogenesis and metabolism that fuel breast tumorigenesis
Defining the Molecular Mechanisms and Clinical Implications of p66ShcA as a Driver of the Epithelial to Mesenchymal Transition in Breast Cancer
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