Modulation of synaptic transmission by GABA and metabotropic glutamate receptors

GABA 和代谢型谷氨酸受体对突触传递的调节

• 批准号: 402594-2011
• 负责人: Kumar, Ujendra
• 金额: $ 1.97万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Group
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=550972
• 关键词: Modulation; synaptic; transmission; GABA; metabotropic

Gamma-amino butyric acid (GABA) and glutamate are major neurotransmitters in the central nervous system. Sensory information from the periphery going through the spinal cord is filtered by a mechanism called presynaptic inhibition. In this proposal studies are designed to examine the involvement of certain GABA and glutamate receptors in modulation of transmission between central brain cells and in presynaptic inhibition. We are looking at novel strategies examining what happens to function when different receptors co-localize or form receptor complexes. These studies will further our understanding of mechanisms involved in processing of sensory information in the spinal cord and activity in brain pathways. They will help in developing comprehensive therapeutic strategies to treat pain, epilepsy, memory disorders, etc.

γ-氨基丁酸（GABA）和谷氨酸是中枢神经系统中的主要神经递质。来自外周的感觉信息通过脊髓被一种称为突触前抑制的机制过滤。在这个提议中，研究旨在检查某些GABA和谷氨酸受体在中枢脑细胞之间的传输调制和突触前抑制中的参与。我们正在寻找新的策略，研究当不同的受体共同定位或形成受体复合物时，功能会发生什么。这些研究将进一步加深我们对脊髓感觉信息处理机制和脑通路活动的理解。它们将有助于制定综合治疗策略，以治疗疼痛、癫痫、记忆障碍等。