Myokines as a novel link between exercise metabolism and inflammation

肌因子作为运动代谢和炎症之间的新联系

• 批准号: 435807-2013
• 负责人: Little, Jonathan
• 金额: $ 2.11万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=552886
• 关键词: Myokines; novel; link; between; exercise

Recently, it was discovered that muscle contraction and exercise can cause skeletal muscle to secrete hormone-like substances, termed myokines, that have the potential to communicate with other tissues. This new discovery raises the possibility that cytokines or other factors released from contracting muscle might influence the function of other cells and tissues during exercise. However, the biological roles and cellular effects of most myokines are completely unknown. Because exercise has been shown to modulate inflammation, this novel research program will test the hypothesis that exercise-induced myokines have anti-inflammatory effects. A combination of projects ranging from experiments in isolated immune cells to studies in exercising humans will determine whether myokines influence inflammatory processes at the cellular level. Results will provide new discoveries to improve the fundamental understanding of how muscles might "talk" to other organs and will highlight novel mechanisms to explain how exercise affects physiological function. These findings will help advance understanding in the fields of muscle physiology, immunology, and metabolism. Future application of this research could involve industrial development and commercialization of synthetic myokines to alter inflammation in humans or other animals. In addition to new scientific discoveries, this integrative research program will contribute to the training of a cohort of current and future Canadian scientists across a spectrum of advanced research methodologies.

最近，人们发现肌肉收缩和运动可以导致骨骼肌分泌激素样物质，称为肌肉激动素，具有与其他组织沟通的潜力。这一新发现提出了一种可能性，即收缩肌肉释放的细胞因子或其他因素可能会在运动过程中影响其他细胞和组织的功能。然而，大多数肌动蛋白的生物学作用和细胞效应是完全未知的。由于运动已被证明可以调节炎症，这项新的研究计划将检验运动诱导的肌动蛋白具有抗炎作用的假设。从分离免疫细胞的实验到运动人体的研究，一系列项目的结合将确定肌动蛋白是否会在细胞水平上影响炎症过程。结果将提供新的发现，以提高对肌肉如何与其他器官“对话”的基本理解，并将突出新的机制，以解释运动如何影响生理功能。这些发现将有助于增进对肌肉生理学、免疫学和新陈代谢领域的了解。这项研究的未来应用可能涉及合成肌动蛋白的工业开发和商业化，以改变人类或其他动物的炎症。除了新的科学发现，这一综合研究计划还将有助于培训一批当前和未来的加拿大科学家，使他们掌握一系列先进的研究方法。