MoBEES: a facility for Molecular Studies in Biodiversity, Ecology, and Environmental Sciences
MoBEES:生物多样性、生态学和环境科学分子研究设施
基本信息
- 批准号:458654-2014
- 负责人:
- 金额:$ 9.49万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Research Tools and Instruments - Category 1 (<$150,000)
- 财政年份:2014
- 资助国家:加拿大
- 起止时间:2014-01-01 至 2015-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Understanding how genes influence the form, function and fitness of living organisms is a fundamental goal of evolutionary genetics. Gene expression analysis is therefore vital to research progress, yet this analysis is often constrained by limits to the statistical resolution and power of conventional real-time PCR. This limit frequently masks biologically important variation in gene expression and prevents a comprehensive and accurate exploration of the functional genomic underpinning of adaptively complex traits. This shortcoming is circumvented, however, by new technology that allows for the ultra-precise measurement of gene expression. This innovation, made possible by 'digital droplet' polymerase chain reaction (ddPCR) technology provides orders of magnitude more precision and sensitivity than conventional gene expression technology. This break-through for molecular biology is analogous to the relationship between the number of pixels and the resolution of a digital image, allowing biologists to 'see' what genes are doing like never before.
了解基因如何影响生物体的形态、功能和适应性是进化遗传学的一个基本目标。因此,基因表达分析对研究进展至关重要,但这种分析往往受到传统实时PCR的统计分辨率和能力的限制。这种限制经常掩盖生物学上重要的基因表达变异,并阻止了全面和准确的探索适应性复杂性状的功能基因组基础。然而,通过允许超精确测量基因表达的新技术,这个缺点被规避了。通过“数字液滴”聚合酶链反应(ddPCR)技术实现的这一创新提供了比传统基因表达技术高几个数量级的精确度和灵敏度。分子生物学的这一突破类似于数字图像的像素数量和分辨率之间的关系,使生物学家能够以前所未有的方式“看到”基因正在做什么。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thompson, Graham其他文献
A mechanical comparison of the locking compression plate (LCP) and the low contact-dynamic compression plate (DCP) in an osteoporotic bone model
- DOI:
10.1097/bot.0b013e318160c84c - 发表时间:
2008-02-01 - 期刊:
- 影响因子:2.3
- 作者:
Snow, Martyn;Thompson, Graham;Turner, Phillip G. - 通讯作者:
Turner, Phillip G.
Providing optimal care for active youth in Canada.
- DOI:
10.36834/cmej.74908 - 发表时间:
2022-07 - 期刊:
- 影响因子:0
- 作者:
Purcell, Laura;Campos, Sarah;Dickinson, Michael;Thompson, Graham;Jevremovic, Tatiana - 通讯作者:
Jevremovic, Tatiana
The Role of Semantic Clustering in Optimal Memory Foraging
- DOI:
10.1111/cogs.12249 - 发表时间:
2015-11-01 - 期刊:
- 影响因子:2.5
- 作者:
Montez, Priscilla;Thompson, Graham;Kello, Christopher T. - 通讯作者:
Kello, Christopher T.
The responsibility to care: lessons learned from emergency department workers' perspectives during the first wave of the COVID-19 pandemic in Canada.
- DOI:
10.1007/s43678-022-00306-z - 发表时间:
2022-08 - 期刊:
- 影响因子:2.4
- 作者:
Lavoie, Bertrand;Bourque, Claude Julie;Cote, Anne-Josee;Rajagopal, Manasi;Clerc, Paul;Bourdeau, Valerie;Ali, Samina;Doyon-Trottier, Evelyne;Castonguay, Veronique;Fontaine-Page, Erika;Burstein, Brett;Desaulniers, Pierre;Goldman, Ran D.;Thompson, Graham;Berthelot, Simon;Lagace, Maryse;Gaucher, Nathalie - 通讯作者:
Gaucher, Nathalie
Ecological interchangeability: supporting team adaptive expertise in moments of disruption.
- DOI:
10.1007/s10459-022-10160-4 - 发表时间:
2022-12 - 期刊:
- 影响因子:4
- 作者:
Cristancho, Sayra;Field, Emily;Lingard, Lorelei;Taylor, Taryn;Hibbert, Kathy;Thompson, Graham;Hibbert, William - 通讯作者:
Hibbert, William
Thompson, Graham的其他文献
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{{ truncateString('Thompson, Graham', 18)}}的其他基金
Genetic basis of social behavior in honey bee and other insect models
蜜蜂和其他昆虫模型社会行为的遗传基础
- 批准号:
RGPIN-2020-05647 - 财政年份:2022
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Genetic basis of social behavior in honey bee and other insect models
蜜蜂和其他昆虫模型社会行为的遗传基础
- 批准号:
RGPIN-2020-05647 - 财政年份:2021
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Genetic basis of social behavior in honey bee and other insect models
蜜蜂和其他昆虫模型社会行为的遗传基础
- 批准号:
RGPIN-2020-05647 - 财政年份:2020
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Understanding the genetic basis of social behaviour from honey bee and other insect models
从蜜蜂和其他昆虫模型中了解社会行为的遗传基础
- 批准号:
RGPIN-2015-06220 - 财政年份:2019
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Understanding the genetic basis of social behaviour from honey bee and other insect models
从蜜蜂和其他昆虫模型中了解社会行为的遗传基础
- 批准号:
RGPIN-2015-06220 - 财政年份:2018
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Understanding the genetic basis of social behaviour from honey bee and other insect models
从蜜蜂和其他昆虫模型中了解社会行为的遗传基础
- 批准号:
RGPIN-2015-06220 - 财政年份:2017
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Understanding the genetic basis of social behaviour from honey bee and other insect models
从蜜蜂和其他昆虫模型中了解社会行为的遗传基础
- 批准号:
RGPIN-2015-06220 - 财政年份:2016
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Understanding the genetic basis of social behaviour from honey bee and other insect models
从蜜蜂和其他昆虫模型中了解社会行为的遗传基础
- 批准号:
RGPIN-2015-06220 - 财政年份:2015
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Behavioural genetics and the evolution of social behaviour
行为遗传学和社会行为的进化
- 批准号:
355966-2009 - 财政年份:2013
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
Behavioural genetics and the evolution of social behaviour
行为遗传学和社会行为的进化
- 批准号:
355966-2009 - 财政年份:2012
- 资助金额:
$ 9.49万 - 项目类别:
Discovery Grants Program - Individual
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