Molecular Center of Health and Disease

整体-摘要 慢性疾病，如心脏病、糖尿病和癌症，是最常见的健康状况 在美国，每10人中就有7人死亡。密西西比州在10个领先城市中有8个位居第一或第二 死亡原因，90%的人口患有1-2种慢性病。虽然慢性病是可以治疗的 通过早期干预、有针对性的医疗治疗以及改善饮食和锻炼，了解 涉及疾病发病的遗传易感性和分子机制有可能阻止疾病的进展 并使个体恢复到更健康的状态。技术的进步现在使人们能够前所未有地洞察 基因组复杂性及其与环境的相互作用 新陈代谢数据集。使用计算将这些数据集与生理信息相结合 方法可以系统地洞察与以下相关的分子、细胞和整体生理学 健康-疾病连续体。我们建议建立一个新的第一阶段科布雷，分子健康中心 促进分子生理学中心主题下的研究，以提高深度 对研究人员进行教育、指导和培训，以在组学应用中创造独特的机会 技术和计算生物学。MCHD将由多个组件组成，包括 行政单位、教育和指导方案、一个试点项目方案、两个研究核心和三个 重大项目调查员。《联合国千年发展目标》的总体目标是：(1)发展基础设施和-- 尖端的基础、临床和翻译方法所必需的最先进的研究核心设施 健康与疾病的连续体。通过核心B，MCHD将增强现有的组学技术(例如，单一 细胞RNAseq和空间转录)，蛋白质组能力，并建立一个新的创新核心，涉及 CRISPR/Cas9基因编辑技术，用于询问基因功能和生物途径；核心C将 建立关键的计算基础设施和计算生物学分析，目前 大学；(2)为有希望的新技术建立有意义的教育、指导计划和研究支持 调查人员将他们培养成多产的、独立资助的调查人员，他们将是有效的 多学科研究团队的合作者。这将通过提供一种“基因和- 《组学学院》(讲授和观察)加强研究人员对分子的理解 和计算方法，一个强大的指导计划，包括一对一和团队指导，职业 发展机会，并通过每个核心提供高水平的研究支持；以及(3)加强 UMMC跨多个学科的调查人员之间的协作和互动，促进合作 在其他IDEA支持的计划之间，包括现有的Cobre、IDEA-CTR和外部合作伙伴关系 密西西比-因布雷。

Overall-Abstract Chronic diseases, such as heart disease, diabetes, and cancer are among the most prevalent health conditions in the United States, responsible for 7 out of every 10 deaths. Mississippi ranks first or second in 8 of 10 leading causes of death, with 90% of the population having 1-2 chronic diseases. While chronic diseases can be treated through early intervention, targeted medical therapies, and improved diet and exercise, an understanding of genetic susceptibility and molecular mechanisms involved in disease onset has the potential to halt progression and return an individual to a healthier state. Advances in technology now allow for unprecedented insight into genome complexity and its interaction with the environment using genomic, transcriptomic, proteomic, and metabolomic datasets. The integration of these datasets with physiological information using computational approaches can provide systematic insight into the molecular, cellular, and overall physiology associated with the health-disease continuum. We propose to establish a new Phase I COBRE, the Molecular Center of Health and Disease (MCHD) to facilitate research under a central theme of molecular physiology to enhance the depth of education, mentorship, and training of researchers to generate unique opportunities in the application of omics technology and computational biology. The MCHD will be comprised of multiple components including an administrative unit, education and mentoring programs, a pilot project program, two research cores, and three major project investigators. The overall objectives of the MCHD are: (1) to develop infrastructure and state-of- the-art research core facilities essential for cutting edge basic, clinical, and translational approaches to study the health and disease continuum. The MCHD, through Core B will enhance existing -omics technology (e.g., single cell RNAseq and spatial transcriptomics), proteomic capabilities, and establish a new innovative core, involving CRISPR/Cas9 gene-editing technology to interrogate gene function and biological pathways; and Core C will establish critical computing infrastructure and computational biology analysis not currently available at the University; (2) to establish meaningful education, mentoring programs, and research support for promising new investigators to nurture them into productive, independently funded investigators, who will be effective collaborators on multidisciplinary research teams. This will be accomplished through offering a “Genetic and - Omics Academy” (didactic instruction and observership) to strengthen researcher understanding of molecular and computational approaches, a robust mentoring program involving one-on-one and team mentoring, career development opportunities, and providing a high level of research support through each core; and (3) to enhance collaborations and interactions among investigators across multiple disciplines at UMMC, promote cooperation between other IDeA supported programs, including existing COBRE, IDeA-CTR, and external partnership with the Mississippi-INBRE.