Center for Molecular Epidemiology

分子流行病学中心

• 批准号: 10630465
• 负责人: MARGARET Rita KARAGAS
• 金额: $ 123.08万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630465
• 关键词: Acceleration; Achievement; Address; Award; Biomedical Research; Centers of Research Excellence; Collaborations; Communities; Consensus; Core Facility; Department chair; Disease; Disease Pathway; Early Intervention; Early identification; Endowment; Ensure; Epidemiologist; Epidemiology; Etiology; Evaluation; Extramural Activities; Faculty; Faculty Recruitment; Fostering; Funding; Future; Grant; Health; Health Personnel; Household; Human; Influentials; Infrastructure; Institution; International; Investigation; Investments; Joints; Leadership; Life Cycle Stages; Mentors; Mentorship; Methods; Molecular; Molecular Epidemiology; New England; Pathogenesis; Pediatric cohort; Peer Review; Phase; Pilot Projects; Policies; Population; Positioning Attribute; Prevention strategy; Principal Investigator; Productivity; Public Health; Publications; Research; Research Infrastructure; Research Personnel; Resources; Schools; Science; Scientific Advances and Accomplishments; Scientist; Services; Strategic Planning; Strategic vision; Structure; Talents; Technology; Training; Trustees; United States National Institutes of Health; biobank; biomedical scientist; burden of illness; career; career development; clinical practice; college; empowerment; forging; health equity promotion; health inequalities; human disease; indexing; innovation; interest; medical schools; member; molecular dynamics; multidisciplinary; next generation; prevent; programs; recruit; research and development; success; tool

ABSTRACT The field of epidemiology has gained increasing prominence in the research community and became a household word in 2020. Epidemiology provides the tools to uncover the underlying causes of human illness and to, in turn, inform clinical practice and preventive strategies, advise policy and regulatory actions, and move scientific advancements forward. In Phases I and II, our Centers of Biomedical Research Excellence (COBRE) Center for Molecular Epidemiology at Dartmouth has effectively advanced research in the field. As the only Center for molecular epidemiology in northern New England and one of the only COBRE programs with this focus nationally, we have successfully recruited and mentored the next generation of independent early career investigators. We further supported established investigators to enlarge their research programs, form new collaborations and integrate the latest biomedical discoveries, innovations, and methods. In doing so, we dramatically grew our research productivity and grant portfolio, as evidenced by the steep rise in the number of publications, presentations, and grants awarded since the inception of our COBRE Center. As part of achieving sustainability, we formed a new Department of Epidemiology and developed innovative cross- disciplinary training grants. Our cohesive Center brings together talented investigators focusing on 1) applying new scientific discoveries and technologies to address major human health concerns, 2) identifying early indicators of disease pathogenesis, and 3) exploring common pathways of disease etiology and progression in human populations, including those related to health inequities. In this Phase III application, we will progress our molecular epidemiology research infrastructure forward to full independence and sustainability. Specifically, we will 1) evolve a state-of-the-art Biorepository and Biospecimen Resource Facility Core that supplies the critical services responsive to the ongoing and future needs of biomedical scientists, 2) expand the pipeline of talented, diverse molecular epidemiologists, and provide the requisite mentorship, career development, and research resources to cultivate cutting-edge research and make investigators competitive for NIH funding, and 3) enhance the governance structure, implementation approaches, stakeholder engagement, and evaluation that will strengthen our Center’s impact, promote its strategic vision, and forge ties with regional and national partners. Our success in Phases I and II, combined with strong institutional support, positions us to serve as a vital resource in molecular epidemiology for Northern New England, for COBRE and IDeA Networks of Biomedical Research Excellence (INBRE) programs, and more broadly.

摘要 流行病学领域在研究界越来越突出，并成为一个 2020年家喻户晓。流行病学为揭示人类疾病的根本原因提供了工具 反过来，为临床实践和预防策略提供信息，为政策和监管行动提供建议， 推动科学进步。在第一和第二阶段，我们的生物医学研究卓越中心 达特茅斯的分子流行病学中心有效地推进了该领域的研究。作为 北方新英格兰唯一的分子流行病学中心，也是唯一的COBRE项目之一 在全国范围内，我们成功地招募和指导了下一代独立的 早期职业调查员我们进一步支持已建立的研究人员扩大他们的研究计划， 形成新的合作，并整合最新的生物医学发现，创新和方法。在这样做时， 我们的研究生产力和赠款组合大幅增长，这一点可以从2008年的 自我们的COBRE中心成立以来，出版物，演示文稿和赠款的数量。一部分 为了实现可持续发展，我们成立了一个新的流行病学系，并开发了创新的交叉学科， 纪律训练赠款。 我们的凝聚力中心汇集了有才华的研究人员，专注于1）应用新的科学发现 2）确定疾病的早期指标 发病机制，和3）探索人类群体中疾病病因和进展的共同途径， 包括与卫生不平等有关的问题。在第三阶段的申请中，我们将在分子水平上 流行病学研究基础设施的完全独立性和可持续性。具体而言，我们将1） 发展最先进的生物储存库和生物标本资源设施核心， 服务响应生物医学科学家的持续和未来的需求，2）扩大管道， 有才华的，多样化的分子流行病学家，并提供必要的指导，职业发展， 研究资源，以培养尖端研究，使研究人员有竞争力的NIH资金， 3)加强治理结构、实施方法、利益攸关方参与和评估 这将加强我们中心的影响力，促进其战略愿景，并与区域和国家建立联系， 伙伴我们在第一阶段和第二阶段的成功，加上强有力的机构支持，使我们成为一个 北方新英格兰分子流行病学的重要资源，COBRE和IDEA网络， 生物医学研究卓越（INBRE）计划，更广泛。