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Assessing the immunomodulatory properties of yeast using primary intestinal epithelial cells and bovine macrophages

Assessing the immunomodulatory properties of yeast using primary intestinal epithelial cells and bovine macrophages
使用原代肠上皮细胞和牛巨噬细胞评估酵母的免疫调节特性
批准号:
462113-2014
负责人:
Karrow, Niel
金额:
$0.83万
依托单位:
依托单位国家:
加拿大
项目类别:
Engage Plus Grants Program
财政年份:
2014
资助国家:
加拿大
项目状态:
已结题
起止时间:
2014-01-01 至 2015-12-31

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中文摘要
翻译
由于酵母益生菌及其细胞壁成分(CWCS)正被用于治疗包括人类在内的不同物种的肠道炎症性疾病,它们可能有助于预防约翰氏病,约翰氏病是一种由禽型分枝杆菌引起的反刍动物慢性炎症性肠道疾病。副结核(MAP)。在我们之前的研究中,我们开发了体外试验,使我们能够使用MAP作为靶标病原体来评估特定酵母CWCS对牛乳腺上皮细胞(Mac-T)的抗粘连特性。此外,牛巨噬细胞系(BoMac)被用来评估潜在的酵母CWC免疫调节特性。拟议的研究将跟进这项研究,并集中于潜在的
英文摘要
Since yeast probiotics and their cell wall components (CWCs) are being used to treat enteric inflammatory diseases in different species including humans, they may be useful for preventing Johne's disease, a chronic inflammatory bowel disease of ruminants caused by Mycobacterium avium spp. paratuberculosis (MAP). In our previous study, we developed in vitro assays that allowed us to assess the anti-adhesive properties of specific yeast CWCs using MAP as a target pathogen on bovine mammary epithelial cells (Mac-T). Additionally, a bovine macrophage cell line (BoMac) was used to assess potential yeast CWC immunomodulatory properties. The proposed study will follow-up this research and focus on the potential
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