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Assessing the immunomodulatory properties of yeast using primary intestinal epithelial cells and bovine macrophages

Assessing the immunomodulatory properties of yeast using primary intestinal epithelial cells and bovine macrophages
使用原代肠上皮细胞和牛巨噬细胞评估酵母的免疫调节特性
批准号：
462113-2014
负责人：
Karrow, Niel
金额：
$0.83万
依托单位：
University of Guelph
依托单位国家：
加拿大
项目类别：
Engage Plus Grants Program
财政年份：
2014
资助国家：
加拿大
项目状态：
已结题
起止时间：
2014-01-01 至 2015-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=556604
关键词：
Assessingimmunomodulatorypropertiesyeastusing

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Since yeast probiotics and their cell wall components (CWCs) are being used to treat enteric inflammatory diseases in different species including humans, they may be useful for preventing Johne's disease, a chronic inflammatory bowel disease of ruminants caused by Mycobacterium avium spp. paratuberculosis (MAP). In our previous study, we developed in vitro assays that allowed us to assess the anti-adhesive properties of specific yeast CWCs using MAP as a target pathogen on bovine mammary epithelial cells (Mac-T). Additionally, a bovine macrophage cell line (BoMac) was used to assess potential yeast CWC immunomodulatory properties. The proposed study will follow-up this research and focus on the potential
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