Impact of Maternal Diet on Small Ruminant Colostrum Bioactives and Postnatal Health

母亲饮食对小反刍动物初乳生物活性和产后健康的影响

基本信息

  • 批准号:
    567566-2021
  • 负责人:
  • 金额:
    $ 5.1万
  • 依托单位:
  • 依托单位国家:
    加拿大
  • 项目类别:
    Alliance Grants
  • 财政年份:
    2021
  • 资助国家:
    加拿大
  • 起止时间:
    2021-01-01 至 2022-12-31
  • 项目状态:
    已结题

项目摘要

Canadian sheep production is majorly hampered by lamb mortalities that occur within 10 days of birth, which amounts to an estimated annual loss of approximately $180,000/year (~$250/lamb) in Ontario. Insufficient availability of nutrients during early life is one of the main causes of young animal morbidity and mortality, where colostrum is their main nutrient source. Colostrum contains many essential bioactives crucial for providing passive immunity to lambs, and "friendly" microbes that steer normal offspring development. Since colostrum quality is partially determined by maternal diet, there is potential to optimize maternal diet to improve colostrum quality and lamb robustness. Deficiency of Selenium (Se) can impair fertility, induce abortions, and lead to neonatal weakness or death shortly after birth. Supplementation of maternal diets with Se during late pregnancy can increase colostrum immunoglobulin G (IgG) that supports neonatal immunity. However, previous studies emphasize that dietary use of inorganic Se, which has lower absorption, is less effective than organic sources. Since Se levels are variable in soils across Ontario and Canada, this study is imperative for producers to have a strategy to enhance Se levels in animal feed. The proposed research aims to enhance lamb resilience by improving colostrum quality and passive transfer of colostrum bioactives and increasing the diversity of the lamb gut microbiome by the inclusion of organic Se in pre-partum ewe diets. A cutting-edge "omics" approach employing NextGen techniques will be employed to assess colostrum quality, passive transfer of bioactives and microbiome diversity in lambs. This multidisciplinary study will improve our understanding of colostrum bioactives and how organic Se improves colostrum quality and overall growth of lambs & reduces mortality. Beneficiaries of this project will be sheep producers, who will benefit from having an economical nutritional strategy to improve colostrum quality and postnatal lamb robustness that will add to the overall profitability and sustainability of herds. Additionally, this project will extensively characterize ovine colostrum and provide new insights into colostrum bioactives; which may be developed as value-added products.
加拿大绵羊生产主要受到羔羊出生后 10 天内死亡的影响,预计安大略省每年损失约 180,000 美元(约 250 美元/只羔羊)。生命早期营养不足是幼年动物发病和死亡的主要原因之一,而初乳是幼年动物的主要营养来源。初乳含有许多对为羔羊提供被动免疫力至关重要的重要生物活性物质,以及引导后代正常发育的“友好”微生物。由于初乳质量部分取决于母体饮食,因此有可能优化母体饮食以提高初乳质量和羔羊的健壮性。缺乏硒 (Se) 会损害生育能力、诱发流产并导致新生儿虚弱或出生后不久死亡。妊娠后期在母亲饮食中补充硒可以增加初乳免疫球蛋白 G (IgG),从而支持新生儿免疫力。然而,之前的研究强调,膳食中使用吸收率较低的无机硒,其效果不如有机来源。由于安大略省和加拿大土壤中的硒含量存在差异,因此这项研究对于生产者制定提高动物饲料中硒含量的策略至关重要。拟议的研究旨在通过改善初乳质量和初乳生物活性物质的被动转移以及通过在产前母羊日粮中添加有机硒来增加羔羊肠道微生物组的多样性来增强羔羊的恢复能力。采用下一代技术的尖端“组学”方法将用于评估羔羊的初乳质量、生物活性物质的被动转移和微生物组多样性。这项多学科研究将增进我们对初乳生物活性物质以及有机硒如何提高初乳质量和羔羊整体生长并降低死亡率的了解。该项目的受益者将是绵羊生产者,他们将受益于经济的营养策略,以提高初乳质量和产后羔羊的健壮性,从而提高牛群的整体盈利能力和可持续性。此外,该项目将广泛表征绵羊初乳,并为初乳生物活性提供新的见解;可以将其开发为增值产品。

项目成果

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科研奖励数量(0)
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Karrow, Niel其他文献

Impact of heat stress on dairy cattle and selection strategies for thermotolerance: a review.
  • DOI:
    10.3389/fvets.2023.1198697
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    3.2
  • 作者:
    Cartwright, Shannon L.;Schmied, Julie;Karrow, Niel;Mallard, Bonnie A.
  • 通讯作者:
    Mallard, Bonnie A.

Karrow, Niel的其他文献

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{{ truncateString('Karrow, Niel', 18)}}的其他基金

Neuroendocrine-immune (NEI) system programming of zebrafish embryos and larva: Implications for stress resilience, disease resistance, and longevity
斑马鱼胚胎和幼虫的神经内分泌免疫(NEI)系统编程:对应激恢复能力、抗病能力和寿命的影响
  • 批准号:
    RGPIN-2019-03903
  • 财政年份:
    2022
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Discovery Grants Program - Individual
Neuroendocrine-immune (NEI) system programming of zebrafish embryos and larva: Implications for stress resilience, disease resistance, and longevity
斑马鱼胚胎和幼虫的神经内分泌免疫(NEI)系统编程:对应激恢复能力、抗病能力和寿命的影响
  • 批准号:
    RGPIN-2019-03903
  • 财政年份:
    2021
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Discovery Grants Program - Individual
Assessment and genetics of stress resilience in dairy cattle
奶牛应激恢复能力的评估和遗传学
  • 批准号:
    530546-2018
  • 财政年份:
    2020
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Collaborative Research and Development Grants
Neuroendocrine-immune (NEI) system programming of zebrafish embryos and larva: Implications for stress resilience, disease resistance, and longevity
斑马鱼胚胎和幼虫的神经内分泌免疫(NEI)系统编程:对应激恢复能力、抗病能力和寿命的影响
  • 批准号:
    RGPIN-2019-03903
  • 财政年份:
    2020
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Discovery Grants Program - Individual
Assessment and genetics of stress resilience in dairy cattle
奶牛应激恢复能力的评估和遗传学
  • 批准号:
    530546-2018
  • 财政年份:
    2019
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Collaborative Research and Development Grants
Penicillium and Fusarium mycotoxin assessment using bovine intestinal epithelial cells (IEC) and co-cultured IEC + macrophages, and remediation with yeast mycotoxin binders
使用牛肠上皮细胞 (IEC) 和共培养的 IEC 巨噬细胞评估青霉菌和镰刀菌霉菌毒素,并使用酵母霉菌毒素结合剂进行修复
  • 批准号:
    532378-2018
  • 财政年份:
    2019
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Collaborative Research and Development Grants
Neuroendocrine-immune (NEI) system programming of zebrafish embryos and larva: Implications for stress resilience, disease resistance, and longevity
斑马鱼胚胎和幼虫的神经内分泌免疫(NEI)系统编程:对应激恢复能力、抗病能力和寿命的影响
  • 批准号:
    RGPIN-2019-03903
  • 财政年份:
    2019
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Discovery Grants Program - Individual
Assessment and genetics of stress resilience in dairy cattle
奶牛应激恢复能力的评估和遗传学
  • 批准号:
    530546-2018
  • 财政年份:
    2018
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Collaborative Research and Development Grants
Genetic markers and Bovine Johne's disease
遗传标记和牛约翰氏病
  • 批准号:
    496214-2016
  • 财政年份:
    2018
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Collaborative Research and Development Grants
Pre- and post-natal programming of the neuroendocrine-immune system: Implications for stress resilience, disease resistance, and longevity
神经内分泌免疫系统的产前和产后规划:对应激恢复能力、抗病能力和长寿的影响
  • 批准号:
    RGPIN-2018-04806
  • 财政年份:
    2018
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Discovery Grants Program - Individual

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果蝇Maternal Haploid 蛋白调控胚胎发育的分子机制研究
  • 批准号:
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  • 批准年份:
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相似海外基金

Impact of Maternal Diet on Small Ruminant Colostrum Bioactives and Postnatal Health
母亲饮食对小反刍动物初乳生物活性和产后健康的影响
  • 批准号:
    567566-2021
  • 财政年份:
    2022
  • 资助金额:
    $ 5.1万
  • 项目类别:
    Alliance Grants
The impact of maternal diet pre-pregnancy and during gestation on early childhood behavioral problems
孕前和妊娠期间母亲饮食对儿童早期行为问题的影响
  • 批准号:
    471885
  • 财政年份:
    2022
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    $ 5.1万
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    Fellowship Programs
How Socioeconomic Status and Perinatal Maternal Diet Impact Infant Social Development: a longitudinal study utilizing the NBAS and fNIRS
社会经济状况和围产期母亲饮食如何影响婴儿社会发展:利用 NBAS 和 fNIRS 的纵向研究
  • 批准号:
    2590833
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    2021
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    $ 5.1万
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改善肥胖母亲饮食对后代心理健康的影响
  • 批准号:
    nhmrc : GNT1161418
  • 财政年份:
    2019
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    $ 5.1万
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The Impact of Maternal Western Style Diet on Immune Cell Function and Development of Non-Alcoholic Fatty Liver Disease
母亲西式饮食对免疫细胞功能和非酒精性脂肪肝发展的影响
  • 批准号:
    9910883
  • 财政年份:
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  • 资助金额:
    $ 5.1万
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The Impact of Maternal Western Style Diet on Immune Cell Function and Development of Non-Alcoholic Fatty Liver Disease
母亲西式饮食对免疫细胞功能和非酒精性脂肪肝发展的影响
  • 批准号:
    10022108
  • 财政年份:
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    $ 5.1万
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The Impact of Maternal Western Style Diet on Immune Cell Function and Development of Non-Alcoholic Fatty Liver Disease
母亲西式饮食对免疫细胞功能和非酒精性脂肪肝发展的影响
  • 批准号:
    10461980
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    $ 5.1万
  • 项目类别:
The Impact of Maternal Western Style Diet on Immune Cell Function and Development of Non-Alcoholic Fatty Liver Disease
母亲西式饮食对免疫细胞功能和非酒精性脂肪肝发展的影响
  • 批准号:
    10242778
  • 财政年份:
    2019
  • 资助金额:
    $ 5.1万
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MATERNAL INFLAMMATION, DIET AND GUT MICROBIOME IN HIV: IMPACT ON INFANT OUTCOMES
HIV 感染中的母体炎症、饮食和肠道微生物组:对婴儿结局的影响
  • 批准号:
    9762133
  • 财政年份:
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  • 资助金额:
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Impact of Maternal Diet and Supplements on Breast Milk Composition
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    9912500
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