Assessment and genetics of stress resilience in dairy cattle
奶牛应激恢复能力的评估和遗传学
基本信息
- 批准号:530546-2018
- 负责人:
- 金额:$ 4.44万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Collaborative Research and Development Grants
- 财政年份:2018
- 资助国家:加拿大
- 起止时间:2018-01-01 至 2019-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Dairy cattle are routinely subjected to a variety of stressors that negatively impact health and fertility, welfare and production. Health and climate experts predict that exposure to stressors (i.e. pathogens, fungal mycotoxins and extreme temperature events) will increase as climate conditions continue to destabilize. Since antimicrobials are now less available for preventing and treating livestock disease, there is a need to explore alternative strategies, such as genetic selection for increased stress resilience, to enhance animal health; it is anticipated that stress resilient animals will be healthier, live longer, and be more productive. In the proposed study, we plan to develop an immune stress challenge for dairy calves using microbial-associated molecular patterns (MAMPs) so that dairy cattle populations can be stress-phenotyped, which is not currently possible. This novel health phenotype will then be used to calculate heritability estimates, explore associations with other measured health and production traits, and carry out a genome-wide association study (GWAS) to identify genetic markers associated with stress responsiveness. Lastly, resilience of stress-phenotyped animals to climate-associated stressors will be assessed. Given the wide-ranging impacts of stress on animal health and production, it is anticipated that development of this stress model will allow Canadian breeding companies such as the SEMEX Alliance to carry out genomic selection to improve dairy cattle health and production well into the future.
奶牛经常受到各种压力,对健康和生育力,福利和生产产生负面影响。健康和气候专家预测,随着气候条件继续不稳定,暴露于压力源(即病原体、真菌毒素和极端温度事件)的情况将增加。由于现在用于预防和治疗牲畜疾病的抗菌剂越来越少,因此需要探索替代策略,例如增加压力恢复力的遗传选择,以增强动物健康;预计压力恢复力动物将更健康,寿命更长,生产力更高。在拟议的研究中,我们计划使用微生物相关分子模式(MAMP)为奶牛开发免疫应激挑战,以便奶牛群体可以进行应激表型分析,这是目前不可能的。然后,这种新的健康表型将被用于计算遗传力估计,探索与其他测量的健康和生产性状的关联,并进行全基因组关联研究(GWAS),以确定与应激反应相关的遗传标记。最后,将评估压力表型动物对气候相关压力源的恢复力。鉴于压力对动物健康和生产的广泛影响,预计这种压力模型的开发将使加拿大育种公司(如SEMEX联盟)能够进行基因组选择,以改善奶牛健康和生产。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Karrow, Niel其他文献
Impact of heat stress on dairy cattle and selection strategies for thermotolerance: a review.
- DOI:
10.3389/fvets.2023.1198697 - 发表时间:
2023 - 期刊:
- 影响因子:3.2
- 作者:
Cartwright, Shannon L.;Schmied, Julie;Karrow, Niel;Mallard, Bonnie A. - 通讯作者:
Mallard, Bonnie A.
Karrow, Niel的其他文献
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{{ truncateString('Karrow, Niel', 18)}}的其他基金
Neuroendocrine-immune (NEI) system programming of zebrafish embryos and larva: Implications for stress resilience, disease resistance, and longevity
斑马鱼胚胎和幼虫的神经内分泌免疫(NEI)系统编程:对应激恢复能力、抗病能力和寿命的影响
- 批准号:
RGPIN-2019-03903 - 财政年份:2022
- 资助金额:
$ 4.44万 - 项目类别:
Discovery Grants Program - Individual
Neuroendocrine-immune (NEI) system programming of zebrafish embryos and larva: Implications for stress resilience, disease resistance, and longevity
斑马鱼胚胎和幼虫的神经内分泌免疫(NEI)系统编程:对应激恢复能力、抗病能力和寿命的影响
- 批准号:
RGPIN-2019-03903 - 财政年份:2021
- 资助金额:
$ 4.44万 - 项目类别:
Discovery Grants Program - Individual
Impact of Maternal Diet on Small Ruminant Colostrum Bioactives and Postnatal Health
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- 批准号:
567566-2021 - 财政年份:2021
- 资助金额:
$ 4.44万 - 项目类别:
Alliance Grants
Assessment and genetics of stress resilience in dairy cattle
奶牛应激恢复能力的评估和遗传学
- 批准号:
530546-2018 - 财政年份:2020
- 资助金额:
$ 4.44万 - 项目类别:
Collaborative Research and Development Grants
Neuroendocrine-immune (NEI) system programming of zebrafish embryos and larva: Implications for stress resilience, disease resistance, and longevity
斑马鱼胚胎和幼虫的神经内分泌免疫(NEI)系统编程:对应激恢复能力、抗病能力和寿命的影响
- 批准号:
RGPIN-2019-03903 - 财政年份:2020
- 资助金额:
$ 4.44万 - 项目类别:
Discovery Grants Program - Individual
Assessment and genetics of stress resilience in dairy cattle
奶牛应激恢复能力的评估和遗传学
- 批准号:
530546-2018 - 财政年份:2019
- 资助金额:
$ 4.44万 - 项目类别:
Collaborative Research and Development Grants
Penicillium and Fusarium mycotoxin assessment using bovine intestinal epithelial cells (IEC) and co-cultured IEC + macrophages, and remediation with yeast mycotoxin binders
使用牛肠上皮细胞 (IEC) 和共培养的 IEC 巨噬细胞评估青霉菌和镰刀菌霉菌毒素,并使用酵母霉菌毒素结合剂进行修复
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532378-2018 - 财政年份:2019
- 资助金额:
$ 4.44万 - 项目类别:
Collaborative Research and Development Grants
Neuroendocrine-immune (NEI) system programming of zebrafish embryos and larva: Implications for stress resilience, disease resistance, and longevity
斑马鱼胚胎和幼虫的神经内分泌免疫(NEI)系统编程:对应激恢复能力、抗病能力和寿命的影响
- 批准号:
RGPIN-2019-03903 - 财政年份:2019
- 资助金额:
$ 4.44万 - 项目类别:
Discovery Grants Program - Individual
Genetic markers and Bovine Johne's disease
遗传标记和牛约翰氏病
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496214-2016 - 财政年份:2018
- 资助金额:
$ 4.44万 - 项目类别:
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Pre- and post-natal programming of the neuroendocrine-immune system: Implications for stress resilience, disease resistance, and longevity
神经内分泌免疫系统的产前和产后规划:对应激恢复能力、抗病能力和长寿的影响
- 批准号:
RGPIN-2018-04806 - 财政年份:2018
- 资助金额:
$ 4.44万 - 项目类别:
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