The neural basis of memory

记忆的神经基础

• 批准号: FT230100476
• 负责人: Prof Lucy Palmer
• 金额: $ 77.55万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT230100476
• 关键词: neural; basis; memory

Although they define us, our knowledge about how, and where, memories are processed and stored within the brain is still in its infancy. This project aims to investigate the morphological and functional changes that occur in cortical neurons during memory formation. By recording from both mouse and human neurons, this study will bridge the gap in knowledge between the heavily-investigated rodent brain and the human brain and advance our knowledge on how remote memories are formed in individual neurons within the frontal cortex of the brain. These findings will highlight potential neural mechanisms that might be awry in cases of memory loss and amnesia.

虽然它们定义了我们，但我们对记忆如何以及在何处在大脑中处理和存储的知识仍处于起步阶段。本项目旨在研究大脑皮层神经元在记忆形成过程中的形态和功能变化。通过记录小鼠和人类的神经元，这项研究将弥合严重研究啮齿动物大脑和人类大脑之间的知识差距差距，并推进我们对大脑额叶皮层内单个神经元如何形成远程记忆的知识。这些发现将突出潜在的神经机制，可能是错误的情况下，记忆丧失和健忘症。