Probing fundamental mechanics of the spine: Normal and injury mechanics

探索脊柱的基本力学：正常和损伤力学

• 批准号: 36516-2012
• 负责人: McGill, Stuart
• 金额: $ 3.42万
• 依托单位: University of Waterloo
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=568743
• 关键词: Probing; fundamental; mechanics; spine; Normal

Low back and cervical spine pain and injury is a major cost to Canadians. The spine is a very complex neural, muscular and skeletal system. However, it thrives on optimal mechanical loading so that it becomes painful and disabled when the mechanical loading is either too much or too little. The focus of this work is directed towards understanding biomechanical function of the spine and related tissues, and using this fundamental knowledge as a foundation, to ultimately develop better pain prevention and rehabilitation approaches. For example, our work deciphering injury mechanisms has shown that disc bulging and herniation have a distinct mechanical cause (repeated and prolonged flexion) which can justify developments for prevention approaches. Over the past 25 years of NSERC funding a highly detailed anatomical model of the thoracolumbar spine has been developed that utilizes the biological signals characterizing movement and muscle activation from each subject. In this way unique insight is obtained into the consequences of the strategies of every individual in terms of tissue stress distribution, and stability of the structure. For the tenure of the next grant, major thrusts include the addition of a cervical spine, and a pelvis with hips to probe basic mechanisms of function from the perspective of the full spine/pelvis. We anticipate discoveries related to how regional spine mechanics influence hip mechanics and vice versa, for example. Another uniqueness in our approach is to combine both in vivo and in vitro techniques. We continue to explore the process of intervertebral disc damage with a focus on documenting the cascade of damage from the endplate, trabecular bone and annulus together with collaborative work to restore function with bio-polymer augmentation following a sealing process of the nucleus compartment.

下背部和颈椎疼痛和损伤是加拿大人的主要成本。脊柱是一个非常复杂的神经、肌肉和骨骼系统。然而，它在最佳机械负荷下蓬勃发展，因此当机械负荷过多或过少时，它会变得痛苦和残疾。这项工作的重点是了解脊柱和相关组织的生物力学功能，并以这些基础知识为基础，最终开发出更好的疼痛预防和康复方法。例如，我们对损伤机制的研究表明，椎间盘膨出和突出有一个独特的机械原因（重复和长时间屈曲），这可以证明预防方法的发展是合理的。在过去的25年中，NSERC资助了一个非常详细的胸腰椎解剖模型，该模型利用了表征每个受试者运动和肌肉激活的生物信号。通过这种方式，获得了对每个人在组织应力分布和结构稳定性方面的策略的后果的独特见解。 在下一个资助的任期内，主要的重点包括增加颈椎和骨盆与髋关节，以从整个脊柱/骨盆的角度探索基本的功能机制。例如，我们预计会发现区域脊柱力学如何影响髋关节力学，反之亦然。我们方法的另一个独特之处是将体内和体外技术联合收割机结合起来。我们继续探索椎间盘损伤的过程，重点记录终板、骨小梁和纤维环的级联损伤，并在髓核室密封过程后通过生物聚合物增强恢复功能。