Parental influences on recovery after early brain injury

父母对早期脑损伤后康复的影响

• 批准号: 312374-2011
• 负责人: Gibb, Robbin
• 金额: $ 1.75万
• 依托单位: University of Lethbridge
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571731
• 关键词: Parental; influences; recovery; after; early

Injury to the brain is associated with a wide range of behavioural sequelae that may severely compromise the cognitive and motor capacities of the individual, leading to a significant decrement in the quality of life. Brain injury can occur at anytime during the lifespan but some stages of life pose a greater risk for damage than others. Particularly vulnerable times to experience brain injury are during certain periods of gestation and early infancy. The sensitivity of the brain to perinatal injury therefore provides an important reason for studying factors that might influence outcomes from damage to the infant brain. Furthermore, by documenting the functional deficits and resulting morphology following brain injury, we can gain insight into the nature of the normal ontogenetic processes that occur within the brain and how they support behaviour. The research proposed includes and examination of how maternal and paternal experience in the prenatal period influences the developing brain and modulates outcome after perinatal brain injury. In addition, I propose to study how environmental influences in the postnatal period can alter developmental trajectories set in the prenatal period. In summary, the focus of the proposed research is on the role of parental experience (either prenatal or preconception) on brain development and plasticity in offspring. The goal is to further understand the impact that pre-birth experience has on the wiring of the developing brain and ultimately how it recovers from a perinatal cortical injury. This research should provide a deeper understanding of how very early experiences shape brain responses to later experiences.

脑损伤与一系列行为后遗症相关，可能严重损害个体的认知和运动能力，导致生活质量显著下降。脑损伤可能在一生中的任何时候发生，但在生命的某些阶段比其他阶段造成更大的损伤风险。特别容易遭受脑损伤的时期是在妊娠期和婴儿早期。因此，大脑对围产期损伤的敏感性为研究可能影响婴儿大脑损伤结果的因素提供了重要的理由。此外，通过记录脑损伤后的功能缺陷和形态学，我们可以深入了解大脑内正常个体发生过程的本质，以及它们如何支持行为。研究建议包括和检查在产前期间母亲和父亲的经验如何影响发育中的大脑和调节围产儿脑损伤后的结果。此外，我建议研究出生后的环境影响如何改变产前设定的发育轨迹。综上所述，本研究的重点是父母经历（产前或孕前）对后代大脑发育和可塑性的影响。其目的是进一步了解出生前的经历对发育中的大脑的影响，并最终了解大脑如何从围产期皮层损伤中恢复过来。这项研究应该能让我们更深入地了解早期经历是如何影响大脑对后来经历的反应的。