The role of myosin surface loops 1 and 2 in regulating the load-dependent power-stroke and ATP kinetics during muscle contraction

肌球蛋白表面环 1 和 2 在调节肌肉收缩过程中负载依赖性动力冲程和 ATP 动力学中的作用

• 批准号: 327310-2011
• 负责人: Rassier, Dilson
• 金额: $ 2.26万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=571980
• 关键词: role; myosin; surface; loops; regulating

Vital functions of human life are performed by small molecules that transform chemical energy into mechanical work. These so-called molecular motors are responsible for transport, division and motility inside the cells. One of these molecular motors is myosin, which is present in muscles and is responsible for contraction and force production. The coordinated action of many myosin molecules results in muscle contraction. Consequently, the magnitude of the movements induced by myosin molecules is directly associated with the force produced by the muscles. The current project seeks to use new, cutting-edge technologies to evaluate the mechanisms by which these molecules use chemical energy to perform their work. This research has far-reaching implications, as understanding the molecular mechanisms of contraction is mandatory to understand the molecular mechanisms of musculoskeletal function.

人类生命的重要功能是由小分子完成的，小分子将化学能转化为机械功。这些所谓的分子马达负责细胞内的运输、分裂和运动。其中一个分子马达是肌球蛋白，它存在于肌肉中，负责收缩和力量的产生。许多肌球蛋白分子的协同作用导致肌肉收缩。因此，肌球蛋白分子引起的运动的大小与肌肉产生的力直接相关。目前的项目寻求使用新的尖端技术来评估这些分子利用化学能进行工作的机制。这项研究具有深远的意义，因为了解收缩的分子机制对于了解肌肉骨骼功能的分子机制是强制性的。