Molecular mechanisms of muscle contraction

肌肉收缩的分子机制

• 批准号: RGPIN-2016-05317
• 负责人: Rassier, Dilson
• 金额: $ 5.25万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630196
• 关键词: Molecular; mechanisms; muscle; contraction

Muscle contraction is driven by the molecular motor myosin II while attached to actin filaments. Myosin molecules transform chemical energy extracted from adenosine tri-phosphate (ATP) into mechanical work. After an initial attachment between myosin and actin, ATP is hydrolyzed, and phosphate (Pi) and subsequently ADP are released from myosin. The molecule undergoes a conformational change - the power stroke - producing force and sliding the actin filament. The molecular mechanisms behind the conversion of chemical energy released from ATP into the myosin power stroke, and its amplification into muscle contraction is not well understood.

肌肉收缩是由分子马达肌球蛋白II驱动，同时连接到肌动蛋白丝。肌球蛋白分子将从三磷酸腺苷（ATP）中提取的化学能转化为机械功。在肌球蛋白和肌动蛋白之间的初始附着之后，ATP被水解，并且磷酸盐（Pi）和随后的ADP从肌球蛋白释放。这个分子经历了一个构象的变化--动力冲程--产生力并使肌动蛋白丝滑动。从ATP释放的化学能转化为肌球蛋白动力冲程，并将其放大为肌肉收缩的分子机制尚未完全了解。