Integrated Microsensors and Microdevices for Diagnostics and Prosthetics

用于诊断和修复的集成微传感器和微型设备

• 批准号: 341231-2012
• 负责人: Chodavarapu, Vamsy
• 金额: $ 1.82万
• 依托单位: McGill University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=572205
• 关键词: Integrated; Microsensors; Microdevices; Diagnostics; Prosthetics

The proposed research program aims to develop sensors and microdevices for real-time biological and chemical monitoring for point-of-care diagnostics, chronic diseases, and traumatic medical conditions. These sensors and microdevices take advantage of several established and emerging integrative technologies including Complimentary Metal-Oxide Semiconductor (CMOS) microelectronics and photonics for signal detection and processing, nanostructured materials for high sensitivity detection, bio-/chemical- recognition elements for high specificity detection, micro-/nano- fabrication for sensor miniaturization, and microfluidics for world-to-sensor interfaces. The proposed research consists of three research themes: (1) integrated biological and chemical sensor microsystems, (2) biomedical microdevices and silicon carbide neural prosthesis, and (3) porous nanostructured materials enabled devices. In the proposed research, we will target sensors towards important issues being faced by large patient populations such as monitoring of metabolism for obesity, blood glucose level for diabetes, blood oxygen demand for hypoxia conditions, metabolic compounds related to aging and genetic disorders and infectious diseases due to pathogenic bacteria. We will research biomedical microdevices to measure various physiological conditions including blood pressure for stroke, ocular pressure for glaucoma, strain sensor to measure bladder volume in patients with urinary dysfunction, and acceleration sensor for cardiac pacing. We aim to develop ultra-long reinforced silicon carbide based neural electrode arrays as front-ends of Brain Machine Interfaces to help people suffering with paralysis to lead normal daily activities. The developed biological and chemical sensors and biomedical microdevices have the potential to play an important role in our personal wellbeing and social and economic growth and development. Further, the requested funding will allow train the next generation of bioengineers, well rooted and adept in design and production of bio-/chemical- sensors, biomedical microdevices, and nanostructured materials, needed to tackle complex challenges in health sciences.

拟议的研究计划旨在开发用于实时生物和化学监测的传感器和微型设备，用于即时诊断、慢性疾病和创伤性医疗条件。这些传感器和微器件利用了几种成熟的和新兴的集成技术，包括用于信号检测和处理的互补金属氧化物半导体（CMOS）微电子和光子学，用于高灵敏度检测的纳米结构材料，用于高特异性检测的生物/化学识别元件，用于传感器小型化的微/纳米制造，以及用于世界与传感器接口的微流体。本研究包括三个研究主题：(1)集成生物和化学传感器微系统；(2)生物医学微设备和碳化硅神经假体；(3)多孔纳米结构材料启用设备。在拟议的研究中，我们将把传感器定位于大量患者群体面临的重要问题，如监测肥胖的代谢、糖尿病的血糖水平、缺氧条件下的血氧需求、与衰老和遗传疾病相关的代谢化合物以及由致病菌引起的传染病。我们将研究用于测量各种生理状况的生物医学微设备，包括用于中风的血压、用于青光眼的眼压、用于测量尿功能障碍患者膀胱容量的应变传感器和用于心脏起搏的加速度传感器。我们的目标是开发基于超长增强碳化硅的神经电极阵列，作为脑机接口的前端，帮助瘫痪患者进行正常的日常活动。发达的生物和化学传感器和生物医学微型设备有潜力在我们的个人福祉和社会经济增长和发展中发挥重要作用。此外，所要求的资金将允许培训下一代生物工程师，他们扎根并擅长设计和生产生物/化学传感器、生物医学微设备和纳米结构材料，这些都是应对健康科学中复杂挑战所需要的。