Integrated CMOS based sensors microsystems for biochemical monitoring

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The integration of complimentary metal-oxide semiconductor (CMOS) integrated circuits (ICs), micro/nano technologies, and photonics continues to increase and shows a great promise for the development of a variety of devices and technologies that can pervasively impact all aspects of our society. The long term objective of the proposed research is to investigate, design, and develop sensor microsystems through the integration of CMOS based devices and systems with a variety of existing and emerging biochemical recognition elements including enzymes, DNA, organic/inorganic dyes, and functional nanoparticles. These microsystems will be useful in sensing, imaging, diagnostic or therapeutic applications for in-hospital/out-of-hospital monitoring, disease/epidemics prevention, environmental monitoring, food/water safety, and national security. To this end, during the five year period of this proposed research one can expect a variety of novel sensor microsystems that: [i] are miniaturized and battery-operated for ubiquitous applicability, [ii] have integrated stimulation, detection, and signal processing/transmission components, [iii] are self-contained and can be easily deployed, [iv] can simultaneously detect/quantify multiple analytes in a sample, [v] are simple and inexpensive to construct and operate, [vi] are accurate, precise, and reliable, and [vii] provide adequate detection limits and selectivity. The activities in the proposed research are divided into three themes: (A) CMOS based phase fluorometric platform for biochemical monitoring, (B) CMOS integrated porous nanostructured sensors, and (C) Lab-on-a-chip sensor microsystems.