Integrated CMOS based sensors microsystems for biochemical monitoring

互补金属氧化物半导体（CMOS）集成电路（IC）、微米/纳米技术和光子学的集成持续增加，并且显示出开发各种设备和技术的巨大前景，这些设备和技术可以广泛地影响我们社会的各个方面。拟议研究的长期目标是通过将基于CMOS的设备和系统与各种现有和新兴的生化识别元件（包括酶，DNA，有机/无机染料和功能纳米颗粒）集成，研究，设计和开发传感器微系统。这些微系统将在传感、成像、诊断或治疗应用中发挥作用，用于医院内/医院外监测、疾病/流行病预防、环境监测、食品/水安全和国家安全。为此，在这项拟议研究的五年期间，人们可以期待各种新型传感器微系统，它们：[i]是小型化的和电池供电的，以用于普遍适用性，[ii]具有集成的刺激、检测和信号处理/传输组件，[iii]是独立的并且可以容易地部署，[iv]可以同时检测/量化样品中的多种分析物，[v]构造和操作简单且便宜，[vi]准确、精确且可靠，并且[vii]提供足够的检测限和选择性。在拟议的研究活动分为三个主题：（A）基于CMOS的相位荧光平台的生化监测，（B）CMOS集成的多孔纳米结构传感器，和（C）芯片上的实验室传感器微系统。

The integration of complimentary metal-oxide semiconductor (CMOS) integrated circuits (ICs), micro/nano technologies, and photonics continues to increase and shows a great promise for the development of a variety of devices and technologies that can pervasively impact all aspects of our society. The long term objective of the proposed research is to investigate, design, and develop sensor microsystems through the integration of CMOS based devices and systems with a variety of existing and emerging biochemical recognition elements including enzymes, DNA, organic/inorganic dyes, and functional nanoparticles. These microsystems will be useful in sensing, imaging, diagnostic or therapeutic applications for in-hospital/out-of-hospital monitoring, disease/epidemics prevention, environmental monitoring, food/water safety, and national security. To this end, during the five year period of this proposed research one can expect a variety of novel sensor microsystems that: [i] are miniaturized and battery-operated for ubiquitous applicability, [ii] have integrated stimulation, detection, and signal processing/transmission components, [iii] are self-contained and can be easily deployed, [iv] can simultaneously detect/quantify multiple analytes in a sample, [v] are simple and inexpensive to construct and operate, [vi] are accurate, precise, and reliable, and [vii] provide adequate detection limits and selectivity. The activities in the proposed research are divided into three themes: (A) CMOS based phase fluorometric platform for biochemical monitoring, (B) CMOS integrated porous nanostructured sensors, and (C) Lab-on-a-chip sensor microsystems.