Novel methods and instruments for accurate tracking of ionizing radiation delivery for medical physics applications

用于精确跟踪医学物理应用中的电离辐射传递的新方法和仪器

基本信息

批准号：
385773-2013
负责人：
Archambault, Louis
金额：
$ 1.53万
依托单位：
Université Laval
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2015
资助国家：
加拿大
起止时间：
2015-01-01 至 2016-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=572899
关键词：
Novel methods instruments accurate tracking

项目摘要

The goal of this work is to create new instruments and methods for guaranteeing that complex radiation treatments can be delivered safely and accurately thus improving chances of success. Three specific aims are being pursued. (1) To develop a radiation dose detector capable of online measurement of radiation doses in three dimensions. This would be the first detector capable of measuring a complete radiation treatment in real-time with millimeter-size precision. Its use for radiotherapy quality control would be an improvement over the current approach of measuring the dose only in a limited number of planes, which leaves a large part of the dose distribution unverified. (2) To develop a miniature tissue-equivalent detector array for accurate in vivo measurement. This unobtrusive detector array will provide precise radiation dose measurements while patients are being treated. Furthermore, our novel approach for signal processing will allow checking the integrity of the detector response during measurements. Integrity checks are important for in vivo measurements because mechanical stress or other hazards could cause erroneous dose readings. (3) To automatically track anatomical changes happening during the course of radiation treatments. A software will be developed to analyze images acquired regularly during the course of radiation treatments to detect the amplitude and location of anatomical changes. We will then put these changes in relation with the planned dose distribution and the location of sensitive organs at risk to detect deviation from the intended plan and adapt it accordingly.

这项工作的目的是创建新的工具和方法，以确保可以安全，准确地提供复杂的辐射处理，从而提高成功的机会。正在追求三个具体目标。（1）开发一个能够在三个维度上在线测量辐射剂量的辐射剂量检测器。这将是第一个能够以毫米大小的精度实时测量完整辐射处理的检测器。它用于放射疗法质量控制将是对仅在有限数量的平面中测量剂量的当前方法的改进，这使得未经验证的大部分剂量分布。（2）开发一个微型组织等效的检测器阵列，以精确的体内测量。在接受治疗的患者时，这种不引人注目的检测器阵列将提供精确的辐射剂量测量。此外，我们的新型信号处理方法将允许检查测量过程中检测器响应的完整性。完整性检查对于体内测量很重要，因为机械应力或其他危害可能会导致剂量读数错误。（3）自动跟踪辐射处理过程中发生的解剖变化。将开发软件以分析在放射线处理过程中定期获得的图像，以检测解剖变化的幅度和位置。然后，我们将根据计划的剂量分布以及有风险的敏感器官的位置进行这些更改，以检测与预期计划的偏差并相应地调整。