Novel antibiotics for treatment of bovine mastitis / Nouveaux antibiotiques pour le traitement de la mammite bovine

最近，我们的研究发现了一种新的细菌抗生素靶点。这个新的靶标是一种具有调节功能的RNA分子（鸟嘌呤核糖开关），显然对某些引起动物感染的细菌至关重要。我们还发现了一种类似药物的小分子，它能够结合鸟嘌呤核开关，阻止必要基因的表达，从而起到杀菌作用。我们进一步证明了该化合物在小鼠和奶牛乳腺内金黄色葡萄球菌感染（乳腺炎）的实验治疗中的抗菌活性。在礼来加拿大公司及其动物保健成分（Elanco）的帮助下，拟议的研发项目旨在优化奶牛行业兽医使用的新型抗生素。

Recently, our research led to the discovery of a new antibiotic target for bacteria. This new target is an RNA molecule with a regulatory function (a guanine riboswitch) apparently essential to certain bacteria causing infections in animals. We also identified a small drug-like molecule able to bind the guanine riboswitch and prevent expression of essential genes with subsequent bactericidal action. We further demonstrated the antibacterial activity of this compound in experimental therapies for Staphylococcus aureus intramammary infections (mastitis) in both mice and cows. With the help of Lilly Canada, Inc., and its animal health component (Elanco), the proposed R&D Project aims at optimizing the novel antibiotic for veterinary use in the dairy industry.