Molecular basis of bacterial small-colony variants / Base moléculaire des variants à petites colonies chez les bactéries

细菌小菌落变体的分子基础/基础分子变体 à petites colonies chez les bactéries

• 批准号: RGPIN-2015-05916
• 负责人: Malouin, Francois
• 金额: $ 2.77万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=629685
• 关键词: Molecular; basis; bacterial; small; colony

Staphylococcus aureus (SA) and antibiotic resistant methicillin-resistant SA (MRSA) often cause chronic and difficult-to-treat infections. SA/MRSA are able to generate Small-Colony Variants (SCVs), which have been linked to persistent infections. The ability of SA/MRSA to switch to SCVs and vice versa seems to be an integral part the infection process leading to persistence. Compared to their normal counterparts, bacterial SCVs produce high amounts of protective biofilms (extracellular matrix in which bacteria are embedded). SCVs also have a great ability to survive and persist within host cells, a property that protects them from the host immune response. The switch to SCVs also facilitates the development of antibiotic resistance making SA/MRSA infections even more difficult to treat.

金黄色葡萄球菌（SA）和抗生素耐甲氧西林耐药SA （MRSA）经常引起慢性和难以治疗的感染。SA/MRSA能够产生与持续感染有关的小菌落变体（scv）。SA/MRSA转换为scv的能力，反之亦然，似乎是导致持久性感染过程的一个组成部分。与正常的scv相比，细菌scv产生大量的保护性生物膜（细菌嵌入的细胞外基质）。scv还具有很强的在宿主细胞内存活和持续存在的能力，这一特性保护它们免受宿主免疫反应的影响。向scv的转变也促进了抗生素耐药性的发展，使SA/MRSA感染更难治疗。