Development of a toxicity index for metabolites associated to chemical and/or biological degradation from petroleum products

在加拿大和魁北克，石油碳氢化合物对土地的污染是一种趋势， 严重的环境问题。虽然石油的降解技术（化学和/或生物） 产品在行业中广泛使用，以前的研究只评估了全球实现的百分比， 降解最终，碳氢化合物的分解会导致脂肪酸、醇类的形成 和CO2，但在此过程中可能出现比原始产品更多的有毒代谢物。伟大信念具有 非常重要的是，制定毒性指数，用于表征与 石油产品降解埃努特克公司是一家位于Pointe-Claire（魁北克）的公司，专门从事 （c）在确定受污染土地和地下水的特性以及土壤补救办法方面发挥重要作用。埃努特克公司 使用越来越受欢迎的原位处理技术来修复受污染的场地。但这 方法对油品降解效果不理想，降解产生的代谢产物有毒性影响 原始碳氢化合物的来源没有阐明。在这种情况下，Enutech Inc.有兴趣评估 在原位处理过程中与不同降解途径相关的代谢物的毒性影响， 以确定哪种降解途径产生最低的毒性影响。为了解决这个问题， Enutech Inc.，该项目包括评估石油代谢物的毒性，从化学和/或 生物降解技术，然后开发一个可靠的毒性指标，可用于现场 污染的土地。因此，与我在UQUMM的研究实验室的合作对Enutech至关重要 公司，因为我们在生物毒性测试领域拥有强大的专业知识。多年来，我们 一直致力于研究几种污染物的毒性机制，以开发风险评估生物测定法 利用藻类和水生植物。这种可靠方法的发展将允许快速检测 石油代谢物引起的毒性。因此，该项目将允许公司验证安全性 它的净化技术和获得一个新的专业水平。

In Canada and in Quebec, the contamination of land by petroleum hydrocarbons represents a current and serious environmental problem. Although degradation techniques (chemical and/or biological) of petroleum products are widely used in the industry, previous studies had only evaluated the global achieved percentage of degradation. Ultimately, the decomposition of hydrocarbons will lead to the formation of fatty acids, alcohols and CO2, but more toxic metabolites than the original product can appear during the process. Therefore, it is of great importance to develop a toxicity index for the characterization of toxic metabolites associated to petroleum products degradation. Enutech inc. is a firm located in Pointe-Claire (Québec) and specialized in the characterization of contaminated land and groundwater as well as in soil remediation approaches. Enutech inc. uses a more and more acclaimed technique as in situ treatment to rehabilitate contaminated sites. However, this method for oil products degradation is not optimal and the toxicity impact of degradation generated metabolites from original hydrocarbons is not elucidated. In this context, Enutech inc. is interested in to evaluate the toxicity impact of metabolites related to different route of degradation during in situ treatment processing and to determine which degradation pathway generates the lowest toxicity impact. To solve this problematic of Enutech inc., this project consist to assess the toxicity of petroleum metabolites obtained from chemical and/or biological degradation techniques and then to develop a reliable toxicity index which can be used for in-situ contaminated land. Therefore, this partnership with my research laboratory at UQÀM is essential for Enutech inc., since we possess a strong expertise in the field of bioassay toxicity testing. During many years, we have been working in toxicity mechanisms of several pollutants for the development of risk assessment bioassays using algae and aquatic plants. The development of this reliable method will permit a rapid detection of toxicity induced by petroleum metabolites. Therefore, this project will allow the company to validate the safety of its decontamination techniques and accessing a new level of expertise.