Rapid and Reliable Determination of Chemical Species in Human Breath Using Continuous Wave Cavity Ring-Down Spectroscopy

该项目专注于一种提供非侵入性、低成本和早期检测肺癌的设备。它 是基于人体呼气成分的腔衰荡光谱(CRDS)。Picomole Inc.，总部位于 蒙克顿-布伦瑞克大学的一项研究表明，肺癌患者呼出的特定化合物中含有一种 中红外(MID-IR)中的签名。为了有效，诊断需要准确地测量 在中红外光谱中的几个波长的吸收，这对于CRDS是可行的。这个项目的目标是 提高测量的可靠性，并通过概念验证原型验证该方法， 这是最近完工的。这将通过增强设备的能力来实现，例如通过减少 测量时间，提高了激光光源的频率、模式和功率稳定性，增加了 增加了可用波长的数量，提高了激光器与CRDS腔的耦合效率。早些时候 肺部疾病的检测将通过消除耗时的方法改变癌症治疗的游戏规则 并产生侵入性手术，大幅提高肺癌患者的存活率。在上面绘制 蒙克顿大学薄膜和光子学研究小组的专业知识，这个项目将 有助于提高Picomole呼气分析设备的竞争力。这个项目的成功 将进一步加强新不伦瑞克和加拿大在生物医学领域的世界领先地位 工业。

This project is focused on an apparatus that offers non-invasive, low cost and early detection of lung cancer. It is based on cavity ring-down spectroscopy (CRDS) of the composition of human breath. Picomole Inc, based in Moncton New-Brunswick, has shown that patients with lung cancer exhale specific compounds with a signature in the mid-infrared (mid-IR). In order to be effective, the diagnostic needs accurate measurement of absorption at several wavelengths in the mid-IR, which is feasible with CRDS. The goal of this project is to increase the reliability of the measurements and validate the methodology with a proof-of-concept prototype, which was recently completed. This will be done by enhancing the capabilities of the device, e.g., by reducing the measurement time, increasing the frequency, modal and power stability of the laser sources, increasing the number of available wavelengths and increasing the coupling efficiency to the lasers to the CRDS cavity. Early detection of pulmonary diseases will be a game changer in cancerotherapy by eliminating time-consuming invasive surgery and producing a substantial increase of the survival rate of lung cancer patients. Drawing on the expertise of the Thin Films and Photonics Research Group at the Université de Moncton, this project will contribute to improving the competiveness of Picomole's breath-analysis device. The success of this project will further strengthen the position of New Brunswick and Canada as a world leader in the bio-medical industry.