Rapid and Reliable Determination of Chemical Species in Human Breath Using Continuous Wave Cavity Ring-Down Spectroscopy

使用连续波腔衰荡光谱快速可靠地测定人类呼吸中的化学物质

• 批准号: 491132-2015
• 负责人: Bisson, JeanFrançois
• 金额: $ 1.82万
• 依托单位: Université de Moncton
• 依托单位国家: 加拿大
• 项目类别: Engage Grants Program
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=586777
• 关键词: Rapid; Reliable; Determination; Chemical; Species

This project is focused on an apparatus that offers non-invasive, low cost and early detection of lung cancer. It is based on cavity ring-down spectroscopy (CRDS) of the composition of human breath. Picomole Inc, based in Moncton New-Brunswick, has shown that patients with lung cancer exhale specific compounds with a signature in the mid-infrared (mid-IR). In order to be effective, the diagnostic needs accurate measurement of absorption at several wavelengths in the mid-IR, which is feasible with CRDS. The goal of this project is to increase the reliability of the measurements and validate the methodology with a proof-of-concept prototype, which was recently completed. This will be done by enhancing the capabilities of the device, e.g., by reducing the measurement time, increasing the frequency, modal and power stability of the laser sources, increasing the number of available wavelengths and increasing the coupling efficiency to the lasers to the CRDS cavity. Early detection of pulmonary diseases will be a game changer in cancerotherapy by eliminating time-consuming invasive surgery and producing a substantial increase of the survival rate of lung cancer patients. Drawing on the expertise of the Thin Films and Photonics Research Group at the Université de Moncton, this project will contribute to improving the competiveness of Picomole's breath-analysis device. The success of this project will further strengthen the position of New Brunswick and Canada as a world leader in the bio-medical industry.

该项目的重点是一种设备，提供非侵入性，低成本和早期检测肺癌。它 基于人体呼吸成分的光腔衰荡光谱（CRDS）。Picomole Inc，总部位于 蒙克顿新不伦瑞克的研究表明，肺癌患者呼出的特定化合物具有 中红外线（Mid-IR）为了有效，诊断需要准确测量 在中红外的几个波长处的吸收，这对于CRDS是可行的。该项目的目标是 提高测量的可靠性，并通过概念验证原型验证方法， 这是最近完成的这将通过增强设备的能力来实现，例如，通过减少 测量时间，增加激光源的频率、模式和功率稳定性， 可利用的波长的数量和增加激光器到CRDS腔的耦合效率。早期 肺部疾病的检测将是癌症治疗的游戏规则改变者， 使肺癌患者的生存率大幅提高。借鉴 在蒙克顿大学的薄膜和光子学研究小组的专业知识，该项目将 有助于提升皮可摩尔呼吸分析装置的竞争力。这个项目的成功 将进一步加强新玩法和加拿大作为生物医学领域世界领导者的地位。 行业