Control of Function and Reactivity in Lanthanide Chemistry by Tailored Ligand Design

通过定制配体设计控制镧系化学中的功能和反应性

• 批准号: RGPIN-2014-03707
• 负责人: Berg, David
• 金额: $ 2.48万
• 依托单位: University of Victoria
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=587370
• 关键词: Control; Function; Reactivity; Lanthanide; Chemistry

The goal of the research described in this proposal is to control the physical and chemical properties of metal ions in compounds. Compounds of the lanthanide metals are the specific focus of this work because they offer important advantages over other metals including higher reactivity, different selectivity and desirable electronic and nuclear properties. Lanthanide chemistry has developed slowly because these metals require special coordination environments to form reactive compounds. In catalysis, for example, a fine balance must be achieved between formation of stable, isolable compounds and metal centres with sufficient reactivity to carry out useful chemical transformations. The new coordination systems described here are designed to achieve two very different purposes: (i) to allow the catalytic formation of C-C, C-N and other bonds in organic molecules and (ii) to form water and air stable lanthanide compounds that have pharmaceutical applications in medical imaging (magnetic resonance, gamma imaging, fluorescence imaging) or therapy (radio-lanthanide complexes as targeted anti-cancer drugs). Access to new organic molecules, facilitated by lanthanide catalysts, is critical to developing new pharmaceuticals and materials with unusual electronic, optical and magnetic properties. Lanthanide compounds have assumed a major role in medicine, acting as the pharmaceutical agent for imaging or targeted tumor destruction. The development of new coordination environments for the lanthanides that forms the basis of this proposal is critical to realizing the practical potential of these unique metals.

本建议所述研究的目标是控制化合物中金属离子的物理和化学性质。稀土金属化合物是这项工作的重点，因为与其他金属相比，它们具有更高的反应活性、不同的选择性以及理想的电子和核性能。稀土化学发展缓慢，因为这些金属需要特殊的配位环境才能形成活性化合物。例如，在催化中，必须在形成稳定的、可分离的化合物和具有足够反应活性的金属中心之间取得微妙的平衡，以便进行有用的化学转化。这里介绍的新配位系统旨在实现两个非常不同的目的：(I)允许有机分子中C-C、C-N和其他键的催化形成；(Ii)形成水和空气中稳定的稀土化合物，这些化合物在医学成像(磁共振、伽马成像、荧光成像)或治疗(作为靶向抗癌药物的放射性稀土配合物)中具有药物应用。在稀土催化剂的推动下，获得新的有机分子对于开发具有不同寻常的电子、光学和磁性的新药物和材料至关重要。稀土化合物在医学上扮演着重要的角色，作为成像或靶向肿瘤破坏的药物。为形成这一提议基础的稀土元素开发新的配位环境，对于实现这些独特金属的实际潜力至关重要。