Toward 3D printed microfluidic artificial lungs for veteran rehabilitation

面向退伍军人康复的 3D 打印微流体人工肺

• 批准号: 9349646
• 负责人: Joseph Allen Potkay
• 金额: --
• 依托单位: VETERANS HEALTH ADMINISTRATION
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9349646
• 关键词: 3D Print; Acute; Acute Lung Injury; Affect; Air; Animal Model; Animal Testing; Animals; Area; Biomimetics; Bioreactors; Blast Injuries; Blood; Blood Platelets; Blood Volume; Blood capillaries; Blood flow; Blood gas; Caliber; Cells; Chemicals; Chromium; Chronic; Chronic Obstructive Airway Disease; Clinical; Development; Devices; Diagnosis; Dialysis procedure; Dimensions; Disease; Dust; Engineering; Exhibits; Experimental Designs; Failure; Filtration; Foreign Bodies; Freedom; Gases; Geometry; Goals; Gulf War; Healthcare Systems; Hour; Human; In Vitro; Laboratories; Length; Lung; Lung diseases; Mechanics; Microfabrication; Microfluidic Microchips; Microfluidics; Modeling; Nature; Paint; Patients; Performance; Photosensitivity; Polyethylene Glycols; Polymers; Population; Positioning Attribute; Printing; Process; Production; Rattus; Rehabilitation therapy; Reporting; Research Proposals; Resistance; Resolution; Respiratory System; Services; Surface; Surveys; System; Techniques; Technology; Testing; Thick; Time; Translating; Veterans; artificial lung; biomaterial compatibility; blood fractionation; blood pump; capillary; clinical application; cost; design; disability; experience; improved; in vivo; operation; polydimethylsiloxane; portability; pressure; pulmonary rehabilitation; respiratory; response; scale up; shear stress; smoke inhalation; surface coating; technology development; two-dimensional; virtual

The long-term goal of this technology development project is improve the rehabilitation of veterans suffering from lung diseases through the development of the first truly portable, biocompatible, artificial lung capable of short and long term respiratory support. Artificial lungs are currently used to rehabilitate lung disease patients; however, significant advances in gas exchange, biocompatibility, and portability are required to fully realize their potential. Microfluidic artificial lungs promise to enable a new class of truly portable artificial lungs through feature sizes and blood channel designs that more closely mimic those found in their natural counterpart. Our small-scale microfluidic artificial lungs achieved the highest gas exchange efficiency of any artificial lung to date. Their lifetimes were significantly improved through the application of biocompatible surface coatings. Initial in vivo demonstrations were performed in an animal (rat) model. However, current microfabrication techniques limit the microfluidic networks in these devices to two dimensions, thereby severely limiting potential device topologies and resulting in inefficient blood distribution networks. Further, current construction techniques may not be suitable for the large area production required for human applications. In this study, we will for the first time harness high resolution 3D polymer printing technology to create large area microfluidic lungs with truly three dimensional blood flow networks and topologies. Constructed 3D printed microfluidic artificial lungs will exhibit gas exchange suitable for some human applications, while using a fraction of the blood contacting surface area, blood volume, and total volume of current commercial devices. The objectives of the current technology-development SPiRE proposal are thus to: 1) Determine optimal 3D printing parameters for microfluidic artificial lungs; and, 2) Construct and test the first 3D printed microfluidic artificial lung in the laboratory using whole animal blood. At the conclusion of this study, we will be ready to test our 3D printed microfluidic artificial lungs in a large animal model. The listed objectives are thus critical to advancing this promising technology towards initial acute systems for veteran pulmonary rehabilitation.

该技术开发项目的长期目标是改善退伍军人苦难的康复 从肺部疾病到开发第一个真正的便携式，生物相容性，人造肺 短期和长期呼吸支持。人造肺目前用于康复肺部疾病患者； 但是，需要完全实现气体交换，生物相容性和可移植性的重大进展 他们的潜力。微流体人造肺有望通过 特征大小和血液通道设计更加模仿自然对应物中的大小。我们的 小规模的微流体人造肺达到了任何人工肺的最高气体交换效率 日期。通过应用生物相容性的表面涂层，它们的寿命得到了显着提高。 在动物（大鼠）模型中进行了初始体内示范。但是，当前的微作业 技术将这些设备中的微流体网络限制为两个维度，从而严重限制 潜在的设备拓扑并导致血液分布网络效率低下。此外，当前的构造 技术可能不适用于人类应用所需的大面积生产。在这项研究中，我们 将首次使用高分辨率3D聚合物打印技术创建大面积微流体 具有真正三维血流网络和拓扑结构的肺。构建的3D印刷微流体 人造肺将表现出适合某些人类应用的气体交换，同时使用一小部分 血接触表面积，血量和当前商业设备的总体积。目标 因此，当前的技术开发尖峰提案是：1）确定最佳3D打印 微流体人造肺的参数； 2）构建和测试第一个3D打印的微流体人造 肺在实验室中使用全动物血液。在这项研究结束时，我们将准备测试我们的3D 大型动物模型中印刷的微流体人造肺。因此，列出的目标对于晋升至关重要 这项有希望的技术朝着老兵肺部康复的初始急性系统。