Photonic sensing platform based on photocorrosion of III-V semiconductor microstructures

基于III-V族半导体微结构光腐蚀的光子传感平台

• 批准号: RGPIN-2015-04448
• 负责人: Dubowski, Jan
• 金额: $ 2.55万
• 依托单位: Université de Sherbrooke
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2015
• 资助国家: 加拿大
• 起止时间: 2015-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=589808
• 关键词: Photonic; sensing; platform; based; photocorrosion

This program aims at exploring both electrochemical and optical properties of III-V semiconductor microstructures comprising heterostructures, quantum wells (QW) or quantum dots (QD) for detection of electrically charged biomolecules immobilized in the vicinity of the surface of such microstructures. The sensitivity of the photoluminescence (PL) effect to band bending of a semiconductor near its surface and modification of both density and nature of the surface states is a well known effect investigated for chemical and biological sensing. We have discovered recently that photocorrosion of a semiconductor heterostructure, if induced under optimized conditions determined by light excitation power, average photon fluence and etching power of a semiconductor surrounding electrolyte, could become a fingerprint of the electrochemical or biochemical reactions taking place at distances, typically, less than 40 nm from the semiconductor surface. The employment of the photocorrosion effect for monitoring surface reactions adds an attractive dimension to the PL-based detection of surface-immobilized biomolecules. We have observed a dissociation process of a stack of epitaxially-grown GaAs/AlGaAs heterojunctions, by employing PL of a GaAs layer buried by such heterostructures. The ability to resolve in situ the photocorrosion of a 1 nm thin GaAs layer has suggested that this approach could offer conditions attractive for monitoring the reactions involving low concentrations of electrically charged biomolecules. Another potential advantage of this “reverse molecular beam epitaxy” concerns in situ biofunctionalization of the photocorrosion-revealed surface of a semiconductor. This could create conditions optimized, e.g., for the grow of high-quality self-assembled monolayers (SAM) that otherwise requires the application of expensive vacuum or high-purity environment controlling equipment. The results of the photocorrosion experiment with a stack of ten (10) GaAs/AlGaAs heterojunctions have suggested that devices with even larger number of heterojunctions could be designed for biofunctionalization and sequential monitoring of biochemical reactions taking place in their vicinity. The innovative character of the photocorrosion-based diagnostics, and the potential of this approach to lead to a new class of (bio)sensors and techniques to monitor surface reactions involving electrically charged molecules, have created the base of a program described in this document. At the center of the program is the development of a quantitative (or a quasi-quantitative) picture of charged molecules interacting in a liquid environment with surfaces of different semiconductor microstructures. This will lead to the construction of a family of devices with stacks of heterostructures, QW or QD optimized for yielding a sensitive diagnostics, rapidly and at a highly attractive cost.

该计划旨在探索III-V族半导体微结构的电化学和光学特性，包括异质结构，量子威尔斯（QW）或量子点（QD），用于检测固定在这种微结构表面附近的带电生物分子。光致发光（PL）效应对半导体在其表面附近的能带弯曲以及表面态的密度和性质的改变的敏感性是用于化学和生物传感研究的众所周知的效应。我们最近发现，如果在由光激发功率、平均光子通量和半导体周围电解质的蚀刻功率确定的优化条件下诱导半导体异质结构的光腐蚀，则半导体异质结构的光腐蚀可以成为在距离半导体表面通常小于40 nm处发生的电化学或生物化学反应的指纹。利用光腐蚀效应监测表面反应为基于PL的表面固定生物分子检测增加了一个有吸引力的维度。我们已经观察到的剥离过程的外延生长的GaAs/AlGaAs异质结的堆栈，通过采用PL的GaAs层埋在这样的异质结构。原位解决1 nm薄GaAs层的光腐蚀的能力表明，这种方法可以提供有吸引力的条件，用于监测涉及低浓度带电生物分子的反应。这种“反向分子束外延”的另一个潜在优点涉及半导体的光腐蚀揭示表面的原位生物功能化。这可以创造优化的条件，例如，用于生长高质量的自组装单层（SAM），否则需要应用昂贵的真空或高纯度环境控制设备。用十（10）个GaAs/AlGaAs异质结的堆叠进行的光腐蚀实验的结果表明，可以设计具有甚至更大数量的异质结的装置用于生物功能化和连续监测在其附近发生的生化反应。基于光腐蚀的诊断的创新特征，以及这种方法导致一类新的（生物）传感器和技术来监测涉及带电分子的表面反应的潜力，已经创建了本文件中描述的程序的基础。该计划的核心是开发带电分子在液体环境中与不同半导体微结构表面相互作用的定量（或准定量）图像。这将导致构建具有异质结构、QW或QD的堆叠的器件家族，其被优化用于快速地并且以高度有吸引力的成本产生灵敏的诊断。